Limit search to available items
Record 6 of 11
Previous Record Next Record
Book Cover
E-book

Title Chemokine receptors and neuroAIDS : beyond co-receptor function and links to other neuropathologies / Olimpia Meucci, editor
Published New York : Springer, ©2010

Copies

Description 1 online resource (xvi, 412 pages) : illustrations
Contents Section I -- HIV Neuroinvasion: Early Events, Late Manifestations -- HIV Co-receptors: The Brain Perspective -- HIV Infection and the PNS -- HIV Latency and Reactivation: Role in Neuropathogenesis -- HIV Coreceptors and Their Roles in Leukocyte Trafficking During Neuroinflammatory Diseases -- Section II -- Chemokine Proteolytic Processing in HIV Infection: Neurotoxic and Neuroimmune Consequences -- Chemokines and Chemokine Receptors in the Brain -- Chemokine Signaling in the Nervous System and Its Role in Development and Neuropathology -- Modulation of Neuronal Cell Cycle Proteins by Chemokine Receptors and Its Role in the Survival of Postmitotic Neurons -- Chemokines and Primary Brain Tumors -- Chemokines as Neuromodulators: Regulation of Glutamatergic Transmission by CXCR4-Mediated Glutamate Release From Astrocytes -- Role of CX3CL1 in Synaptic Activity and Neuroprotection -- Section III -- Interaction Between Opioid and Chemokine Receptors in Immune Cells: Implications for HIV Infection -- Chronic Morphine's Role on Innate Immunity, Bacterial Susceptibility and Implications in Wound Healing -- Opioids, Astroglial Chemokines, Microglial Reactivity, and Neuronal Injury in HIV-1 Encephalitis -- Regulation of Neuronal Chemokine Receptor CXCR4 by?-Opioid Agonists and Its Involvement in NeuroAIDS
Summary Chemokines and their receptors are being recognized as an integral component of the nervous system implicated in fundamental aspects of development and homeostasis, such as neurotransmission, proliferation, differentiation, and neuronal-glial communication. Thus, their involvement in HIV neuropathology goes far beyond the co-receptors role and entails complex interactions of the chemokine system with different cell types and other regulators of neuronal function. The major goal of this volume is to review these topics in order to highlight alterations of chemokine physiology that may contribute to neuroAIDS and other neuropathologies. This book will be of interest to neuroscientists, neurologists, virologists, pharmacologists, and students in these fields. About the Editor: Olimpia Meucci, MD, PhD is a Professor of Pharmacology and Physiology & Microbiology and Immunology at Drexel University College of Medicine in Philadelphia, PA. Since her seminal discovery about the regulation of neuronal signaling by chemokines, her research has primarily focused on the physio-pathological roles of this important class of neuroimmune modulators in the central nervous system and their involvement in neuroAIDS. These studies have significantly contributed to current understanding of the cellular and molecular mechanisms of HIV-related neuropathology including the interaction of the chemokine system with drug of abuse, namely opiates, which continues to be a major area of investigation in the Meucci lab
Bibliography Includes bibliographical references and index
Notes Print version record
In Springer eBooks
Subject Chemokines -- Receptors
AIDS (Disease) -- Complications -- Treatment
HIV infections -- Complications -- Treatment
Nervous system -- Diseases -- Chemotherapy
Toxicology.
Receptors, Chemokine -- physiology
Chemokines -- physiology
Nervous System Diseases -- etiology
Acquired Immunodeficiency Syndrome -- complications
HIV Infections -- complications
Toxicology
toxicology.
MEDICAL -- AIDS & HIV.
HEALTH & FITNESS -- Diseases -- AIDS & HIV.
Receptors, Chemokine -- physiology.
Acquired Immunodeficiency Syndrome -- complications.
HIV Infections -- complications.
Nervous System Diseases -- etiology.
Chemokines -- Receptors.
AIDS (Disease) -- Complications -- Treatment.
HIV infections -- Complications -- Treatment.
Nervous system -- Diseases -- Chemotherapy.
Medicine.
Chemokines -- physiology.
Biomédecine.
Sciences de la vie.
AIDS (Disease) -- Complications -- Treatment
Nervous system -- Diseases -- Chemotherapy
Form Electronic book
Author Meucci, Olimpia.
LC no. 2009930629
ISBN 9781441907936
1441907939
1441907920
9781441907929
Other Titles Chemokine receptors function and neuroAIDS