| Description |
xv, 401 pages : illustrations ; 25 cm |
| Contents |
Machine derived contents note: Part I. Molecular Biology and Natural History: 1. Introduction Patrick Morrison, Shirley Hodgson and Neva Haites -- 2. Overview of clinical genetics of breast cancer Neva Haites and Helen Gregory -- 3. Cowden syndrome and related disorders Charis Eng -- 4. Overview of clinical genetics of ovarian cancer Pierre Chappuis and Will Foulkes -- 5. Ovarian cancer as part of HNPCC and other hereditary colon cancer syndromes Hans Vasen and M. A. Nooy -- 6. Natural history of hereditary breast cancer Dominique Stoppa-Lyonnet, Will Foulkes and Pierre Chappuis -- 7. Pathology of the breast and ovary in mutation carriers Sunil Lakhani and Adrienne M. Flanagan -- 8. Risk estimation for familial breast and ovarian cancer Jenny Chang-Claude and Heiko Becher -- Part II. Screening: 9. Experience of setting up a cancer genetics service Jonathon Gray -- 10. Referral criteria for cancer genetics clinics Diana Eccles -- 11. Service aspects of cancer genetic clinics Neva Haites and Shirley Hodgson -- 12. Cultural and education aspects influencing development of cancer genetics services in different European countries Shirley Hodgson -- 13. Screening, detection and survival patterns of breast and other cancers in high risk families Pl̄ Ml̜ler and Michael Steel -- 14. Screening for familial ovarian cancer Barnaby Rufford, Usha Menon and Ian Jacobs -- Part III. Management: 15. Management of BRCA 1/2 mutation carriers Pierre Chappuis and Will Foulkes -- 16. Management of ovarian cancer Dirk Brinkman and Ian Jacobs -- 17. Prophylactic mastectomy in mutation carriers Gareth Evans, Fiona Lalloo and Andrew Balidam -- 18. Psychosocial aspects of genetic counselling Steven Sutton and Alison Bish -- 19. BRCA 1 and 2 testing: uptake and its measurement Lucy Brooks and Gareth Evans -- 20. Ethical aspects Patrick Morrison and Michael Steel -- 21. Gene therapy of breast and ovarian cancer Richard Kennedy and Patrick Johnston -- 22. Future directions Patrick Morrison, Shirley Hodgson and Neva Haites. -- -- Part 1 Molecular biology and natural history 1 -- 1 Introduction 3 -- Patrick J. Morrison, Shirley V. Hodgson and Neva E. Haites -- 2 Overview of the clinical genetics of breast cancer 6 -- Neva Haites and Helen Gregory -- 3 Cowden syndrome and related disorders 22 -- Charis Eng -- 4 Overview of the clinical genetics of ovarian cancer 43 -- Pierre O. Chappuis and William D. Foulkes -- 5 Ovarian and breast cancer as part of hereditary non-polyposis colorectal -- cancer (HNPCC) and other hereditary colorectal cancer syndromes 73 -- H. F. A. Vasen and M. A. Nooy -- 6 The natural history of hereditary breast cancer 81 -- Pierre O. Chappuis, Dominique Stoppa-Lyonnet, Bernard Asselain and William D. Foulkes -- 7 Pathology of the breast and ovary in mutation carriers 108 -- Sunil R. Lakhani and Adrienne M. Flanagan -- 8 Risk estimation for familial breast and ovarian cancer 125 -- Jenny Chang-Claude and Heiko Becher -- Part 2 Screening 141 -- 9 Developing a cancer genetics service: a Welsh model 143 -- Jonathon Gray -- 10 Referral criteria for cancer genetics clinics -- Diana M. Eccles -- 11 Guidelines for the development of cancer genetics services -- Neva E. Haites, Shirley V. Hodgson and the Scottish Office Working Group on Cancer G, -- 12 Cultural and educational aspects influencing the development of cancer -- genetics services in different European countries -- Shirley V. Hodgson -- 13 Screening, detection and survival patterns of breast and other cancers in -- high-risk families -- PI Moller and C. Michael Steel -- 14 Screening for familial ovarian cancer -- Barnaby Rufford, Usha Menon and lan Jacobs -- Part 3 Management -- 15 Management of BRCA1/2 mutation carriers -- Pierre O. Chappuis and William D. Foulkes -- 16 Management of familial ovarian cancer -- Dirk Brinkmann and lan Jacobs -- 17 Prophylactic mastectomy in mutation carriers -- D. G. R. Evans, F. I. Lalloo and A. D. Baildam -- 18 Psychosocial aspects of genetic counselling for breast and ovarian cancer -- Alison Bish and Steven Sutton -- 19 BRCA1/2 testing: uptake and its measurement -- Lucy Brooks, Andrew Shenton, F. I. Lalloo and D. G. R. Evans -- 20 Breast cancer genetics: ethical, social and insurance issues -- Patrick J. Morrison and C. Michael Steel -- 21 Gene therapy for breast and ovarian cancer -- Richard Kennedy and Patrick G. Johnston -- 22 Future directions -- Patrick J. Morrison, Shirley V. Hodgson and Neva E. Haites |
| Summary |
"This book surveys the ramifications that have arisen from the significant advances in our understanding of the genetic basis of familial breast and ovarian cancer. Written by international experts from Europe and North America, it provides the busy clinician with a contemporary and wide-ranging guide to the latest developments in the diagnosis, genetics, screening, prevention and management of familial breast cancer. In this rapidly advancing field, this book provides an unrivalled source of information, including sections on ethical and insurance issues and the different cultural aspects of breast cancer. The use of recently devised cancer genetics clinics and different referral criteria and patterns to these clinics are also detailed. This book will be of value to all clinical geneticists, oncologists and healthcare professionals involved in screening and counselling programmes."--BOOK JACKET |
| Notes |
'digitally printed first paperback edition 2005' --verso t.p |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Breast -- Cancer.
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Breast -- Cancer -- Genetic aspects.
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Ovaries -- Cancer.
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Ovaries -- Cancer -- Genetic aspects.
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| Author |
Morrison, Patrick J. (Patrick John), 1963-
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Hodgson, S. V.
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Haites, Neva E. (Neva Elizabeth), 1947-
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MyiLibrary.
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| LC no. |
2005282824 |
| ISBN |
9780521017770 paperback |
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0521017777 paperback |
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9780521803731 hardback |
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052180373X hardback |
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