1. General toxicology -- 2. Drug metabolism: inactivation and bioactivation of xenobiotics / Gerard J. Mulder -- 3. Molecular and cellular mechanisms of toxicity / J. Fred Nagelkerke and Bob van de Water -- 4. Teratology / Lennart Dencker and Bengt R Danielsson -- 5. Genotoxicity / Björn Hellman -- 6. Carcinogenicity of drugs / Gerard J. Mulder -- 7. Liver toxicity / J. Fred Nagelkerke -- 8. Kidney toxicity / Bob van de Water -- 9. Toxicity in the respiratory system / Eva Brittebo --10. Immunotoxicity / Camilla Svensson -- 11. Clinical toxicology / Hans Persson -- 12. Safety assessment of pharmaceuticals: regulatory aspects / Jan Willem van der Loan -- 13. Pharmacovigilance / Sten Olsson and Ronald Meyboom