This dissertation identified and characterised a key genetic regulator called Stat5 using zebrafish. Up-regulation of Stat5 led to an increase in blood cells, indicative of pre-leukaemia, whilst down-regulation decreased these cells and caused other defects. This work shows that Stat5 is critical in blood cell maturation and early embryonic development
Notes
Degree conferred 2007
Submitted to the School of Life and Environmental Sciences of the Faculty of Science and Technology, Deakin University
Thesis (Ph.D.)--Deakin University, Victoria, 2006
Bibliography
Includes bibliographical references (pages 177-211)
