| Description |
xvi, 213 pages : illustrations (some color) ; 24 cm |
| Contents |
1. A brief history of genomics -- 2. DNA array formats -- 3. DNA array readout methods -- 4. Gene expression profiling experiments: Problems, pitfalls, and solutions -- 5. Statistical analysis of array data: Inferring changes -- 6. Statistical analysis of array data: Dimensionality reduction, clustering, and regulatory regions -- 7. The design, analysis, and interpretation of gene expression profiling experiments -- 8. Systems biology -- App. A. Experimental protocols -- App. B. Mathematical complements -- App. C. Internet resources -- App. D. CyberT: An online program for the statistical analysis of DNA array data |
| Summary |
"Massive data acquisition technologies, such as genome sequencing, high-throughput drug screening, and DNA arrays are in the process of revolutionizing biology and medicine. Using the mRNA of a given cell, at a given time, under a given set of conditions, DNA microarrays can provide a snap-shot of the level of expression of all the genes in the cell. Such snapshots can be used to study fundamental biological phenomena such as development or evolution, to determine the function of new genes, to infer the role that individual genes or group of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression. The interdisciplinary introduction to DNA arrays will be essential reading for researchers wanting to take advantage of this powerful new technology."--BOOK JACKET |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online version of the print title |
|
System requirements: Internet connectivity, World Wide Web browser, and Adobe Acrobat reader |
|
Mode of access: World Wide Web |
| Subject |
Gene expression.
|
|
DNA microarrays.
|
| Author |
Hatfield, G. Wesley, 1940-
|
|
ebrary, Inc.
|
| LC no. |
2001052862 |
| ISBN |
0521800226 hardback |
|
