| Description |
xiv, 287 pages : illustrations ; 24 cm |
| Contents |
Machine derived contents note: 1 Computers, Operating Systems and the Internet 1 -- 1.1 Computers and Operating Systems 1 -- 1.2 Internet and WWW 5 -- 1.3 The Physical Connection to the Internet 6 -- 1.4 The Logical Connection to the Internet 8 -- 1.5 Internet Services 8 -- 1.5.1 E-mail 8 -- 1.5.2 FTP 11 -- 1.5.3 World Wide Web 16 -- 1.6 Using UNIX 18 -- 1.7 The History of Bioinformatics 23 -- WWW Links 29 -- 2 The Biological Foundations of Bioinformatics 31 -- 2.1 Nucleic Acids and Proteins 31 -- 2.2 Structure of the Nucleic Acids DNA and RNA 31 -- 2.3 The Storage of Genetic Information 33 -- 2.4 The Structure of Proteins 36 -- 2.4.1 Primary Structure 36 -- 2.4.2 Secondary Structure 39 -- 2.5 Tertiary and Quaternary Structure 41 -- WWW Links 43 -- 3 Biological Databases 45 -- 3.1 Biological Knowledge is Stored in Global -- Databases 45 -- 3.2 Primary Databases 46 -- 3.2.1 Nucleotide Sequence Databases 46 -- 3.2.2 Protein Sequence Databases 53 -- 3.3 Secondary Databases 58 -- 3.3.1 PROSITE 58 -- 3.3.2 PRINTS 60 -- 3.3.3 Pfam 61 -- 3.3.4 Interpro 61 -- 3.4 Genotype-Phenotype Databases 62 -- 3.4.1 PhenomicDB 63 -- 3.5 Molecular Structure Databases 64 -- 3.5.1 Protein Data Bank (PDB) 64 -- 3.5.2 SCO P 65 -- 3.5.3 CATH 67 -- 3.5.4 PubChem 67 -- WWW Links 72 -- 4 Sequence Comparisons and Sequence-Based -- Database Searches 75 -- 4.1 Pairwise and Multiple Sequence Comparisons 75 -- 4.2 Database Searches with Nucleotide and Protein -- Sequences 83 -- 4.2.1 Important Algorithms for Database -- Searching 87 -- 4.3 Software for Sequence Analysis 87 -- WWW Links 92 -- 5 The Decoding of Eukaryotic Genomes 95 -- 5.1 The Sequencing of Complete Genomes. 95 -- 5.2 The Characterization of Genomes using -- STS and EST Sequences 96 -- 5.2.1 Sequence Tagged Sites are Landmarks -- in the Human Genome 96 -- 5.2.2 Expressed Sequence Tags 97 -- 5.3 The Implementation of an EST Project 99 -- 5.4 The Identification of Unknown Genes 103 -- 5.5 The Discovery of Splice Variants 105 -- 5.6 Genetic Causes for Individual Differences 108 -- 5.6.1 Pharmacogenetics and Individual -- Medicine 110 -- WWW Links 115 -- 6 Protein Structures and Structure-Based Rational -- Drug Design 117 -- 6.1 Protein Structure 117 -- 6.2 Signal Peptides 118 -- 6.3 Transmembrane Proteins 122 -- 6.4 Analyses of Protein Structures 123 -- 6.4.1 Protein Modeling 124 -- 6.4.2 The Determination of Protein Structures -- by High Throughput Methods 125 -- 6.5 Structure-Based Rational Drug Design 126 -- 6.5.1 A Docking Example 128 -- 6.5.2 Pharmacophore Modeling 131 -- 6.5.3 Successes of Structure-Based Rational -- Drug Design 133 -- WWW Links 136 -- 7 Systems Biology: The Functional Analysis -- of Genomes 139 -- 7.1 The Identification of the Cellular Functions -- of Gene Products 139 -- 7.1.1 Transcriptomics 140 -- 7.1.2 Proteomics 153 -- 7.1.3 Metabolomics 163 -- 7.1.4 Phenomics 166 -- 7.2 Systems Biology 170 -- WWW Links 178 -- 8 Comparative Genome Analyses 181 -- 8.1 The Era of Genome Sequencing 181 -- 8.2 Drug Research at the Target Protein 182 -- 8.3 Comparative Genome Analyses Provide -- Information about the Biology of Organisms 185 -- 8.3.1 Genome Structure 185 -- 8.3.2 Coding Regions 186 -- 8.3.3 Noncoding Regions 188 -- 8.4 Comparative Metabolic Analyses 188 -- 8.4.1 Kyoto Encyclopedia of Genes and Genomes. 191 -- 8.5 Groups of Orthologous Proteins 195 -- WWW Links 199 -- 9 Solutions to the Exercises 201 |
| Notes |
Formerly CIP. Uk |
|
Includes index |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Bioinformatics -- Problems, exercises, etc.
|
|
Bioinformatics.
|
|
Computational Biology.
|
| Genre/Form |
Problems and Exercises.
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Problems and exercises.
|
| Author |
Marhöfer, R. J. (Richard J.)
|
|
Rohwer, A. (Andreas)
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| LC no. |
2007937094 |
| ISBN |
354072799X (hbk.) |
|
9783540727996 (hbk.) |
|
