| Description |
1 online resource (433 pages) |
| Contents |
Cover; Title Page; Copyright; Contents; About the Editor; List of Contributors; Preface; Acknowledgements; Chapter 1 New Applications of Immobilized Metal Ion Affinity Chromatography in Chemical Biology; 1.1 Introduction; 1.2 Principles and Traditional Use; 1.3 A Brief History; 1.4 New Application 1: Non-protein Based Low Molecular Weight Compounds; 1.4.1 Siderophores; 1.4.2 Anticancer Agent: Trichostatin A; 1.4.3 Anticancer Agent: Bleomycin; 1.4.4 Anti-infective Agents; 1.4.5 Other Agents; 1.4.6 Selecting a Viable Target |
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1.5 New Application 2: Multi-dimensional Immobilized Metal Ion Affinity Chromatography1.6 New Application 3: Metabolomics; 1.7 New Application 4: Coordinate-bond Dependent Solid-phase Organic Synthesis; 1.8 Green Chemistry Technology; 1.9 Conclusion; Acknowledgments; References; Chapter 2 Metal Complexes as Tools for Structural Biology; 2.1 Structural Biological Studies and the Major Techniques Employed; 2.2 What do Metal Complexes have to Offer the Field of Structural Biology?; 2.3 Metal Complexes for Phasing in X-ray Crystallography |
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2.4 Metal Complexes for Derivation of Structural Restraints via Paramagnetic NMR Spectroscopy2.4.1 Paramagnetic Relaxation Enhancement (PRE); 2.4.2 Residual Dipolar Coupling (RDC); 2.4.3 Pseudo-Contact Shifts (PCS); 2.4.4 Strategies for Introducing Lanthanide Ions into Bio-Macromolecules; 2.5 Metal Complexes as Spin Labels for Distance Measurements via EPR Spectroscopy; 2.6 Metal Complexes as Donors for Distance Measurements via Luminescence Resonance Energy Transfer (LRET); 2.7 Concluding Statements and Future Outlook; References |
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Chapter 3 AAS, XRF, and MS Methods in Chemical Biology of Metal Complexes3.1 Introduction; 3.2 Atomic Absorption Spectroscopy (AAS); 3.2.1 Fundamentals and Basic Principles of AAS; 3.2.2 Instrumental and Technical Aspects of AAS; 3.2.3 Method Development and Aspects of Practical Application; 3.2.4 Selected Application Examples; 3.3 Total Reflection X-Ray Fluorescence Spectroscopy (TXRF); 3.3.1 Fundamentals and Basic Principles of TXRF; 3.3.2 Instrumental/Methodical Aspects of TXRF and Applications |
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3.4 Subcellular X-ray Fluorescence Imaging of a Ruthenium Analogue of the Malaria Drug Candidate Ferroquine Using Synchrotron Radiation3.4.1 Application of X-ray Fluorescence in Drug Development Using Ferroquine as an Example; 3.5 Mass Spectrometric Methods in Inorganic Chemical Biology; 3.5.1 Mass Spectrometry and Inorganic Chemical Biology: Selected Applications; 3.6 Conclusions; Acknowledgements; References; Chapter 4 Metal Complexes for Cell and Organism Imaging; 4.1 Introduction; 4.2 Photophysical Properties; 4.2.1 Fluorescence and Phosphorescence; 4.2.2 Two-photon Absorption |
| Summary |
Understanding, identifying and influencing the biological systems are the primary objectives ofchemical biology. From this perspective, metal complexes have always been of great assistanceto chemical biologists, for example, in structural identification and purification of essentialbiomolecules, for visualizing cellular organelles or to inhibit specific enzymes. This inorganic sideof chemical biology, which continues to receive considerable attention, is referred to as inorganicchemical biology. Inorganic Chemical Biology: Principles, Techniques and Ap |
| Notes |
4.2.3 Upconversion Luminescence |
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Print version record |
| Subject |
Chemistry, Inorganic.
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Biology, life sciences
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Mineralogical chemistry.
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Biochemical Phenomena
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Metals -- chemistry
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Macromolecular Substances -- chemistry
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Chemistry, Inorganic
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inorganic chemistry.
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Mineralogical chemistry
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Chemistry, Inorganic
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| Form |
Electronic book
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| ISBN |
9781118684252 |
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1118684257 |
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1306684994 |
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9781306684996 |
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