| Description |
1 online resource (1 PDF (152 pages)) : color illustrations, digital file |
| Contents |
Understanding and exploiting protein-protein interactions as drug targets / Giovanna Zinzalla -- Protein-protein interactions : an emerging class of molecular targets for anticancer drugs / Alex W. White, Jitka Soukupová & Andrew D. Westwell -- Druggability of protein-protein interactions / Veronique Hamon & Xavier Morelli -- Chemical library screening approaches to aid the design of protein-protein inhibitors / Luca Laraia & David R. Spring -- Peptides as protein-protein interaction modulators / Erika Nieddu, Luisa Merello & Carlo Bidoia -- Constrained peptide helices / Andrew B. Mahon & Paramjit S. Arora -- Synthesis of peptidomimetic scaffolds / Andrew J. Wilson -- Computational approaches for the design of protein-protein interaction inhibitors / Wenbo Yu, Olgun Guvench & Alexander D. MacKerell Jr. -- Biochemical assays and biophysical tools for inhibitor identification and validation / Adrian Fowkes, Helene Bertrand & Geoff Wells -- Cell-based assays for identifying, validating and optimizing protein-protein interaction modulators / Abigail L. Male & Ali Tavassoli -- Future directions / Alexander L. Breeze -- Index |
| Summary |
The ten chapters of this book provide an understanding of the key aspects in targeting PPIs with synthetic agents in a concise yet comprehensive manner |
| Notes |
Page 152 is blank |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Protein-protein interactions.
|
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Drug development.
|
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Proteins -- metabolism
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Drug Discovery -- methods
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Drug development
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Protein-protein interactions
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| Form |
Electronic book
|
| Author |
Zinzalla, Giovanna, editor
|
|
Future Science Ltd, publisher
|
| ISBN |
9781909453463 |
|
1909453463 |
|
9781909453456 |
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1909453455 |
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