Title Practical oncologic molecular pathology : frequently asked questions / Yi Ding, Linsheng Zhang, editors

Published Cham : Springer, 2021

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Description 1 online resource (446 pages) Series Practical Anatomic Pathology Practical anatomic pathology. Contents Intro -- Preface -- Contents -- Contributors -- Part I: Molecular Methods and Data Analysis in Clinical Molecular Diagnostic Laboratories -- 1: The Molecular Pathobiology of Malignant Process and Molecular Diagnostic Testing for Cancer -- List of Frequently Asked Questions -- Frequently Asked Questions -- Case Presentations -- Case 1 -- Learning Objectives -- Case History -- Initial Work-up -- Histologic Findings -- Molecular Genetic Study -- Final Diagnosis -- Discussion -- Case 2 -- Learning Objectives -- Case History -- Molecular Genetic Studies -- Final Diagnosis -- Clinical Follow-Up Discussion -- Case 3 -- Learning Objectives -- Case History -- Laboratory Findings -- Molecular Genetic Studies -- Final Diagnosis -- Discussion -- Case 4 -- Learning Objective -- Case History -- Molecular Genetic Studies -- Final Diagnosis -- Discussion -- Case 5 -- Learning Objectives -- Case History -- Molecular Genetic Studies -- Final Diagnosis -- Discussion -- References -- 2: Molecular Diagnostic Methods -- List of Frequently Asked Questions -- Frequently Asked Questions -- Case Examples -- Case #1 -- Learning Objectives -- Case History -- Final Diagnosis -- Discussion -- Case #2 Learning Objectives -- Case History -- Laboratory Work-up -- Histologic Findings -- Molecular Genetic Studies -- Final Diagnosis -- Discussion -- NGS Sequencing Results -- Case #3 -- Learning Objectives -- Case History -- Final Diagnosis -- Discussion -- Case #4 -- Learning Objectives -- Case History -- Final Diagnosis -- Discussion -- References -- 3: Bioinformatics Analysis in Molecular Pathology -- List of Frequently Asked Questions -- Frequently Asked Questions -- Cases -- Case 1: HGVS Nomenclature and Rules -- Discussion for Case 1 -- Case 2: Read Depth and Molecular Bar Coding Discussion for Case 2 -- Case 3: FASTQ Format and Mate-Pairs -- Discussion for Case 3 -- Case 4: Variant Filtering -- Discussion for Case 4 -- Case 5: Protected Health Information and Cloud Services -- Discussion for Case 5 -- References -- 4: Quality Assurance and Quality Control in Molecular Diagnostic Laboratories -- List of Frequently Asked Questions -- Frequently Asked Questions -- Case Presentations -- Case 1 -- Learning Objective -- Case History -- Case 2 -- Learning Objective -- Case History -- Case 3 -- Learning Objective -- Case History -- References Part II: Molecular Pathology of Solid and Soft Tissue Tumors -- 5: Breast and Gynecologic Tumors -- List of Frequently Asked Questions -- Frequently Asked Questions -- Case Presentations -- Case 1 -- Case History -- Histologic Finding -- Differential Diagnosis -- Ancillary Studies -- Final Diagnosis -- Discussion -- Case 2 -- History -- HER2 Testing -- Final HER2 Interpretation -- Discussion -- Case 3 -- History -- Gross Findings -- Histologic Findings -- Differential Diagnosis -- Ancillary Studies -- Final Diagnosis -- Discussion -- Case 4 -- History -- Histologic Findings -- MMR Studies Summary This book is a review and high-yield reference on the clinical molecular diagnostics of malignant neoplasms. It aims to address the practical questions frequently encountered in the molecular oncology practice, as well as key points and pitfalls in the clinical interpretation of molecular tests in guiding precision cancer management. The text uses a Q & A format and case presentations, with emphasis on understanding the molecular test methods, diagnosis, classification, risk assessment and clinical correlation. Starting with an update on the molecular biology of cancer, the book focuses on the topics related to molecular diagnostics and genetics-based precision oncology. Separate chapters are dedicated to discussion of the bioinformatics for the analysis of genetic/genomic data generated from molecular assays, and quality control (QC)/quality assurance (QA) programs in the clinical laboratories; both are critical in producing high quality results for clinical care of cancer patients. These are followed by organ system-based reviews and discussions on the molecular genetic abnormalities and related tests covering diverse types of common to rare malignant neoplasms. This book also provides up-to-date knowledge related to malignant neoplasms, discusses the established as well as evolving requirements for pathologic diagnosis of these malignancies. It also discusses the cost effective utilization of molecular tests in clinical oncology. Written by experts in the field, Practical Oncologic Molecular Pathology serves as a valuable reference for practicing pathologists, fellows, residents and other health care professionals Notes Genetic Testing Includes index Online resource; title from PDF title page (SpringerLink, viewed July 27, 2021) Subject Cancer -- Molecular diagnosis. Pathology, Molecular. Neoplasms Neoplasms -- genetics Pathology, Molecular Molecular Medicine Cancer -- Molecular diagnosis Diagnòstic molecular. Càncer. Genre/Form Llibres electrònics. Form Electronic book Author Ding, Yi Zhang, Linsheng ISBN 9783030732271 3030732274

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