| Description |
1 online resource (xii, 396 pages) : color illustrations |
| Contents |
Part I: Cytokines in Inflammatory Disorders -- The Interleukin-1 Family / Charles A. Dinarello and Mihai G. Netea -- IL-6 and Inflammatory Diseases / Daisuke Kamimura, Yasunobu Arima, Toshio Hirano, Hideki Ogura and Masaaki Murakami -- The Roles of IL-17A and IL-17F in Infection and Inflammatory Disorders / Harumichi Ishigame and Susumu Nakae -- IL-18 / Wen Li, Yoshimasa Tanaka and Haruki Okamura -- Interleukin-21: A Pleiotropic Mediator of Immunity and Inflammation with Broad Therapeutic Potential / Rosanne Spolski and Warren J. Leonard -- Interleukin-22: A Bridge Between Epithelial Innate Host Defense and Immune Cells / Xiaoting Wang and Wenjun Ouyang -- IL-23 in Health and Disease / Jonathan P. Sherlock, Luis A. Zuniga and Daniel J. Cua -- IL-36: An Epithelial Cytokine Important in Psoriasis / John E. Sims, Solenne Vigne, Cem Gabay and Jennifer E. Towne -- Anti-TNF Therapy: 20 Years from Our First Therapeutic Adventure / Jagdeep Nanchahal, Peter Taylor, Richard Williams and Marc Feldmann -- Part II: Cytokines in Allergic Disorders -- Interleukin-25: A Key Initiator of Type 2 Immune Responses / Hiroshi Nakajima, Tomohiro Tamachi and Koichi Hirose -- Interleukin-33: A Multifunctional Alarmin that Promotes Both Health and Disease / Kazufumi Matsushita and Tomohiro Yoshimoto -- Thymic Stromal Lymphopoietin (TSLP) / Steven F. Ziegler, Florence Roan, Bryan D. Bell, Thomas A. Stoklasek, Masayuki Kitajima and Hongwei Han -- Part III: Cytokines in Immunological Tolerance and Anti-inflammation -- Interleukin-10: Cytokines in Anti-inflammation and Tolerance / Ashleigh Howes, Philippa Stimpson, Paul Redford, Leona Gabrysova and Anne O'Garra -- Interleukin-27: Regulation of Immune Responses and Disease Development by a Pleiotropic Cytokine with Pro- and Anti-inflammatory Properties / Izuru Mizoguchi, Kaname Higuchi, Kana Mitobe, Ren Tsunoda, Junichiro Mizuguchi and Takayuki Yoshimoto -- Interleukin-35: A Novel Mediator of Peripheral Tolerance / Greg M. Delgoffe and Dario A.A. Vignali |
| Summary |
This book guides the reader through the latest research on the cytokine network, covering signaling pathways, control of the immune response, and potential therapeutics. Different cytokines stimulate diverse responses in various phases of inflammation and immunity, including the innate immune response, the generation of effector T cells, and the development of antibodies by the humoral immune system. It is now clear that the pathophysiology of many infectious, autoimmune, allergic, and malignant diseases can be largely explained by which cytokines are induced and subsequently regulate the cellular responses. In clinical medicine, cytokines are involved in a wide spectrum of diseases. This book describes in three parts the properties and roles of 15 key cytokines under physiological and pathological conditions. Part I presents nine cytokines associated with inflammatory disorders, pro-inflammatory cytokines, and the recently identified new helper T (Th) subset: Th17 cells. Part II gives details of three cytokines associated with allergic disorders, including Th2 responses and recently identified types of innate cells. Part III describes three cytokines that are associated with immunological tolerance and anti-inflammation, including regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and inducible IL-35-producing Treg (iTr35) cells. Cytokines are considered to be important as therapeutic targets for specific agonists or antagonists in numerous immune and inflammatory diseases. The ultimate goal of this book is to facilitate the development of therapeutic treatments for such diseases which has been limited by an insufficient understanding of the biology of cytokines and the complicated network that they create |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Online resource; title from PDF title page (SpringerLink, viewed November 4, 2013) |
| In |
Springer eBooks |
| Subject |
Cytokines.
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Cytokines -- immunology
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Cytokines
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Cytokines
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| Form |
Electronic book
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| Author |
Yoshimoto, Takayuki, editor
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Yoshimoto, Tomohiro, editor
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| ISBN |
9784431544425 |
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4431544429 |
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