| Description |
1 online resource (xi, 260 pages) |
| Series |
Handbook of experimental pharmacology ; v. 206 |
|
Handbook of experimental pharmacology ; v. 206.
|
| Contents |
K-acetylation and its enzymes: overview and new developments / Juliette Adjo Aka, Go-Woon Kim, Xiang-Jiao Yang. -- Biology of HDAC in cancer: the nuclear and epigenetic components / Astrid Hagelkruys, Anna Sawicka, Magdalena Rennmayer, Christian Seiser. -- Deacetylation of nonhistone proteins by HDACs and the implications in cancer / Lirong Peng, Edward Seto. -- Biology and therapeutic implications of HDACs in the heart / Timothy A. McKinsey. -- HDACs in skeletal muscle remodeling and neuromuscular disease / Bryan J. Simmons, Todd J. Cohen, Richard Bedlack, Tso-Pang Yao. -- Rationale for HDAC inhibitor therapy in autoimmunity and trasplantation / Wayne W. Hancock. -- Role of mammalian sirtuins in the regulation of metabolism, aging, and longevity / Akiko Satoh, Liana Stein, Shin Imai. -- Mictochondrial sirtuins in the regulation of mictochondrial activity and metabolic adaption / David B. Lombard, Daniel X. Tishkoff, Jianjun Bao. -- Characterization of nuclear sirtuins: molecular mechanisms and physiological relevance / Debra Toiber, Carlos Sebastian, Raul Mostoslavsky. -- Structural biology of human netal-dependent histone deacetylases / Matthieu Schapira. -- Sirtuin modulators / Sumit S. Mahajan, Vid Leko, Julian A. Simon, Antonio Bedalov |
| Summary |
The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
| Subject |
Histone deacetylase.
|
|
Histone Deacetylases -- physiology
|
|
Histone Deacetylase Inhibitors
|
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Neoplasms -- drug therapy
|
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Sirtuins -- physiology
|
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Histone Deacetylases
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Histone deacetylase
|
| Form |
Electronic book
|
| Author |
Yao, Tso-Pang
|
|
Seto, Edward
|
| ISBN |
9783642216312 |
|
3642216315 |
|
3642216307 |
|
9783642216305 |
|
1283365936 |
|
9781283365932 |
|
9786613365934 |
|
6613365939 |
|
