Title Molecular imaging with reporter genes / edited by Sanjiv Sam Gambhir, Shahriar S. Yaghoubi

Published Cambridge ; New York : Cambridge University Press, 2010

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Description 1 online resource (xiii, 321 pages) : illustrations (some color) Series Cambridge molecular imaging series Cambridge molecular imaging series. Contents Types of imaging reporter genes -- Fluorescent reporter proteins / Robert E. Campbell and Michael W. Davidson -- Revealing biomolecular mechanisms through in vivo bioluminescence imaging / Timothy C. Doyle, Qian Wang, and Christopher H. Contag -- Reporter gene imaging with PET/SPECT June-Key Chung, Joo Hyun Kang, and Keon Wook Kang -- Noninvasive imaging of gene expression with magnetic resonance imaging and magnetic resonance spectroscopy / Mark D. Pagel and James P. Basilion -- Enhancing reporter gene imaging techniques -- Multimodality imaging of reporter gene / Pritha Ray and Sanjiv Sam Gambhir -- Cell-specific imaging of reporter gene expression using a two-step transcriptional amplification strategy / Marxa L. Figueirdo [and others] -- Imaging instrumentations -- Physics, instrumentation, and methods for imaging reporter gene expression in living subjects / Craig S. Levin -- current applications of imaging reporter genes -- Reporter gene imaging of cell signal transduction / Tarik F. Massoud [and others] -- Gene therapy and imaging of transgene expression in living subjects / Shahrihar S. Yaghoubi and Sanjiv Sam Gambhir -- Imaging regulation of endogenous gene expression in living subjects / Vladimir Ponomarev -- Imaging cell trafficking and immune cell activation using PET reporter genes / Evan D. Nair-Gill [and others] -- Imaging reporter genes and stem cells / Martin G. Rodriguez-Porcel and Sanjiv Sam Gambhir -- Clinical applications of reporter gene technology / Iván Peñuelas [and others] Summary "Reporter genes have been used for several decades to study regulation of gene expression in vivo. However, it was little more than a decade ago that a new class of reporter genes was developed for imaging molecular events within living subjects. By following the interactions of protein molecules, researchers can resolve the complex chemical pathways that living cells utilize. This book focuses on this group of imaging reporter genes, starting with detailed descriptions of all reporter genes from different imaging modalities, including optical, MRI, and radionuclide-based imaging. Key scientists in the field explain how to enhance reporter gene imaging utility through instrumentation and the various applications of this technology. This is the first comprehensive book on all aspects of reporter gene imaging, detailing what is known in the field and future goals for research. Investigators in biomedical sciences, physicians, and the biotechnology and pharmaceutical industries will benefit from topics covered here"--Provided by publisher Bibliography Includes bibliographical references and index Notes Print version record Subject Reporter genes. Molecular probes. Diagnostic imaging. Molecular Imaging -- methods Genes, Reporter Molecular Probes Diagnostic Imaging SCIENCE -- Life Sciences -- Biochemistry. Diagnostic imaging Molecular probes Reporter genes Form Electronic book Author Gambhir, Sanjiv Sam Yaghoubi, Shahriar S. (Shahriar Shah), 1975- ISBN 9780511729898 0511729898 0511726600 9780511726606 9780521882330 0521882338 9780511730405 0511730403

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