Front cover; Preface; Contributors; Table of Contents; List of Antibodies to APP and A Proteins; Chapter 1. Biochemical Characterization of Amyloid Precursor Protein; Chapter 2. Assays for Analysis of APP Secretion and Recycling; Chapter 3. Strategies for Crystallizing the N-Terminal Growth Factor Domain of Amyloid Precursor Protein; Chapter 4. Analysis of Amyloid Precursor Protein Processing Protease -Secretase: Tools for Memapsin 2 ( -Secretase) Inhibition Studies; Chapter 5. Assays for Amyloid Precursor Protein -Secretase Activity
Summary
Demonstrating critical techniques utilized in genetics, molecular biology, cell biology and biochemistry to characterize this transmembrane protein, Amyloid Precursor Protein: A Practical Approach describes the most up-to-date research activities. Each technique is presented in the format of a standard protocol with step-by-step instructions for bench scientists carrying out similar studies on APP and other proteins. These protocols form the core of the authors' approach to elucidating the function of a protein. The book contrasts basic and advanced methods to explain how the development of bi
