| Description |
1 online resource (429 p.) |
| Series |
Methods in Signal Transduction Ser |
|
Methods in Signal Transduction Ser
|
| Contents |
Intro -- Half Title -- Series Page -- Title Page -- Copyright Page -- Contents -- Preface -- Editors -- Contributors -- 1. Endogenous Activation and Neurophysiological Functions of Acid-Sensing Ion Channels -- 1.1 Introduction -- 1.2 Endogenous Conditions That May Activate ASICs -- 1.2.1 Metabolic Production of Protons -- 1.2.1.1 Carbon Dioxide -- 1.2.1.2 Lactate -- 1.2.2 Acidification Niche and Proton Generators -- 1.2.2.1 Na+/H+ Exchangers (NHEs) -- 1.2.2.2 Hydrogen Voltage-Gated Channel 1 (Hv1) -- 1.2.2.3 Carbonic Anhydrases (CAs) -- 1.3 ASICs and Neurophysiological Functions |
|
1.3.1 Synaptic Development -- 1.3.2 Synaptic Plasticity -- 1.3.3 Regional Specific Functions of ASICs -- 1.3.3.1 Amygdala -- 1.3.3.2 Retina -- 1.3.3.3 Dorsal Root Ganglia (DRG) -- 1.4 Summary and Outlook -- Acknowledgements -- References -- 2. Acid-Sensing Ion Channels and Synaptic Plasticity: A Revisit -- 2.1 Introduction -- 2.2 Protons and ASICs in Synaptic Transmission -- 2.2.1 Protons Act as a Neurotransmitter in Synaptic Signaling -- 2.2.2 Modulation of Synaptic Transmission by ASICs -- 2.3 ASIC1a in Synaptic Plasticity -- 2.3.1 ASIC1a in LTP -- 2.3.1.1 Hippocampus -- 2.3.1.2 Amygdala |
|
2.3.1.3 ACC -- 2.3.2 ASIC1a in LTD -- 2.3.2.1 Hippocampus -- 2.3.2.2 Insular Cortex -- 2.4 ASICs in Synaptic Remodeling -- 2.5 Summary and Future Perspectives -- Acknowledgements -- References -- 3. Trimeric Scaffold Ligand-Gated Ion Channels -- 3.1 An Introduction of Trimeric Scaffold of Ligand-Gated Ion Channels (TS-LGICs) -- 3.2 Subunit Stoichiometry and Single Subunit Architecture of P2X Receptors and ASIC Channels -- 3.3 Ion Permeation Pathway of P2X Receptors and ASIC Channels -- 3.4 Ligand Recognitions of P2X Receptors and ASIC Channels |
|
3.5 Coordinated Allostery During Channel Activation of P2X Receptors and ASIC Channels -- 3.6 Ionic Selectivity of P2X Receptors and ASIC Channels -- 3.7 Architecture and Function of the Intracellular Domain of P2X Receptors and ASIC Channels -- 3.8 Other Endogenous or Exogenous Agonists of P2X Receptors and ASIC Channels -- 3.9 Perspectives -- Acknowledgments -- References -- 4. Eukaryotic Mechanosensitive Ion Channels -- 4.1 Introduction -- 4.1.1 MS and Novel MA Ion Channels-Concepts and Physiology -- 4.1.1.1 ASICs -- 4.1.1.2 TRP Channels -- 4.1.1.3 TMEM150C -- 4.1.1.4 TMEM63 (OSCA) |
|
4.1.1.5 TMEM120A (TACAN) -- 4.1.1.6 TMEM87A (Elkin1) -- 4.1.2 Piezo Channels-Physiology and Activation Insights -- 4.1.2.1 Piezo Channels Are Bona fide Mechanically Activated Ion Channels -- 4.1.2.2 Structures and Activation Mechanisms of Piezo Channels -- 4.1.2.3 Physiology of Piezo Channels -- 4.2 Conclusion and Future Directions -- References -- 5. Ion Channels in Human Pluripotent Stem Cells and Their Neural Derivatives -- 5.1 Introduction -- 5.1.1 Derivation of Neurons and Glia from hPSCs -- 5.1.2 Models to Study Ion Channel Properties of hPSC Derived Neurons and Glia |
| Notes |
Description based upon print version of record |
|
5.2 Ion Channels in hPSCs |
| Form |
Electronic book
|
| Author |
Wu, Long-Jun
|
| ISBN |
9781000403749 |
|
1000403742 |
|
