Drug delivery to the brain : physiological concepts, methodologies and approaches / Margareta Hammarlund-Udenaes, Elizabeth C.M. de Lange, Robert G. Thorne, editors
Part I. Physiology and basic principles for drug handling by the brain -- Part II. Pharmacokinetic concepts in brain drug delivery -- Part III. Industrial approaches for investigation of potential central nervous system drugs -- Part IV. Strategies for improved central nervous system drug delivery -- Part V. Brain drug delivery in disease conditions
Summary
The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood -brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma
Bibliography
Includes bibliographical references and index
Notes
Online resource; title from PDF title page (ebrary, viewed January 2, 2014)
