| Description |
1 online resource (315 pages) : illustrations |
| Series |
Methods in signal transduction series |
|
Methods in signal transduction.
|
| Contents |
Screening of Ligands for GPCRs ; Screening of Endogenous Ligands for Orphan GPCRs, M. Mori, S. Hinuma, T. Ohtaki, and M. Fujino ; Screening of Ligands for Human GPCRs by the Use of Receptor-Ga ( Fusion Proteins, S. Takeda, H. Suga, and T. Haga ; Screening and Identification of Ghrelin, an Endogenous Ligand for the Growth-Hormone-Secretagogue Receptor, M. Kojima and K. Kangawa ; Ligand Screening of Olfactory Receptors, K. Touhara, S. Katada, T. Nakagawa, and Y. Oka ; Functions and Regulations of GPCRs ; Generation and Phenotypical Analysis of Muscarinic Acetylcholine Receptor Knockout Mice, J. Wess, D. Gautam, S.-J. Han, J. Jeon, C. Li, and C. Deng ; Systematic Mutagenesis of M1 Muscarinic Acetylcholine Receptors, E.C. Hulme ; Analysis of the Regulation of Muscarinic Acetylcholine Receptors, C.J. Van Koppen ; Single-Molecule Analysis of Chemotactic Signaling Mediated by cAMP Receptor on Living Cells, M. Ueda, Y. Miyanaga, and T. Yanagida ; Oligomerization of G Protein-Coupled Purinergic Receptors, H. Nakata, K. Yoshioka, and T. Kamiya Tertiary Structure of GPCRs and Their Ligands ; Methods and Results in X-Ray Crystallography of Bovine Rhodopsin, T. Okada, R. Tsujimoto, M. Muraoka, and C. Funamoto ; Determination of Steric Structure of Muscarinic Ligands Bound to Muscarinic Acetylcholine Receptors: Approaches by TRNOE (Transferred Nuclear Overhauser Effect), H. Furukawa, T. Hamada, H. Hirota, M. Ishiguro, and T. Haga ; Modeling of G Protein-Coupled Receptors for Drug Design, M. Ishiguro ; Index |
| Summary |
"G Protein-Coupled Receptors: Structure, Function, and Ligand Screening is not a revision but rather a continuation of G Protein-Coupled Receptors, published in 1999. This newer work covers techniques in the field of GPCRs, which either were not treated in the original or have since been developed. In particular, it places significant emphasis on the crystal-lography of rhodopsin, which was first discovered in 2000, and is still the only GPCR that has had its atomic structure revealed." "Written by those experts who pioneered the very methods discussed, G Protein-Coupled Receptors: Structure, Function, and Ligand Screening reviews the state of research on orphan GPCRs. Ultimately, the work is intended to elucidate the structural basis for the GPCR-ligand interaction and the molecular mechanisms underlying the function and regulation of GPCRs. This will allow researchers to utilize their interactions with ligands for drug design."--BOOK JACKET |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
G proteins -- Receptors
|
|
Cell receptors.
|
|
Receptors, Cell Surface
|
|
GTP-Binding Proteins -- physiology
|
|
MEDICAL -- Biochemistry.
|
|
Cell receptors
|
|
G proteins -- Receptors
|
| Genre/Form |
Laboratory manuals
|
|
Laboratory manuals.
|
|
Manuels de laboratoire.
|
| Form |
Electronic book
|
| Author |
Haga, Tatsuya
|
|
Takeda, Shigeki
|
| LC no. |
2005040590 |
| ISBN |
1420038273 |
|
9781420038279 |
|
9780849327711 |
|
0849327717 |
|
9780429129889 |
|
0429129882 |
|
