| Description |
1 online resource (401 pages) : color illustrations |
| Contents |
Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Foreword -- Preface -- List of Contributors -- Breast Cancer: A Global Burden -- Brij Nath Tewari1,* and Sanjay Mishra2 -- INTRODUCTION -- Statistics at a Glance: The Burden of Cancer Worldwide -- A brief History of Breast Cancer -- Types of Breast Cancer -- GRADING AND MOLECULAR SUBTYPES OF BREAST CANCER -- Breast Cancer Grading -- Breast Cancer Molecular Subtypes -- Luminal A -- Luminal B -- Basal-like -- HER2 Enriched -- SIGNS, SYMPTOMS AND RISK FACTORS OF BREAST CANCER -- Risk Factors of Breast Cancer -- Age |
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Geographical Variation -- Previous Benign Breast Cancer -- Age at Menarche and Menopause -- Oral Contraceptives -- Breast-feeding -- Breast Density -- Family History of Breast Cancer -- Personal History of Breast Cancer -- Genetic Risk Factors -- Radiation -- Tobacco -- Alcohol -- Diet -- Hormonal Risk Factor -- TUMOR MARKERS -- Types of Molecular Markers -- Diagnostic Markers -- Prognostic Markers -- Predictive Markers -- Companion Diagnostic Markers -- CURRENT DIAGNOSIS AND TREATMENTS OF BREAST CANCER -- Screening and Diagnosis of Breast Cancer -- Mammography -- Overdiagnosis of Breast Cancer |
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Magnetic Resonance Imaging (MRI) -- Breast Ultrasound -- PET Scan -- X-rays -- Biopsy -- Breast Cancer Treatments -- Surgery -- Limitations -- Radiation Therapy -- Internal Radiation Therapy -- Limitations -- Systemic Therapy -- Chemotherapy -- Hormonal Therapy -- Targeted Therapy: Therapy Intended at HER2 -- Other Targeted Drugs -- SUMMARY AND CONCLUDING REMARKS -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- Current Imaging Techniques in Breast Cancer: An Overview -- Garima Suman* and Anurima Patra -- INTRODUCTION -- Anatomy of Breast |
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Clinical Diagnosis of BC -- Why Imaging? -- RADIOLOGICAL MODALITIES USED IN BC DETECTION -- Mammography -- Ultrasonography -- Magnetic Resonance Imaging -- Positron Emission Tomography -- Computed Tomography -- Screening of BC -- ACR BI-RADS -- IMAGE GUIDED BREAST INTERVENTION -- Pre-operative Localization -- Image-guided Breast Lesion Biopsy -- Other Applications -- RECENT ADVANCES IN BREAST IMAGING -- Digital Breast Tomosynthesis -- Advances in Breast Ultrasonography -- Computer-aided Detection -- Magnetic Resonance Spectroscopy -- LIMITATIONS, DRAWBACKS, AND SUMMARY -- CONSENT FOR PUBLICATION |
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CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- An Overview of Genetic, Proteomic and Meta-bolomic Biomarkers in Breast Cancer -- Tarjani Agrawal* -- INTRODUCTION -- BIOMARKERS -- Limitations of Current BC Screening Techniques and the Potential Role of Biomarkers -- Integration of Biomarkers into Current Diagnostic Paradigms -- Commonly Utilized Cancer Biomarkers for BC -- ESTABLISHED BIOMARKERS -- Estrogen and Progesterone Receptors -- Mutation in the ER Gene -- HER2 -- GENOMIC BIOMARKERS FOR BC -- Highly Penetrant BC Genes -- BRCA1 and BRCA2 -- TP53 -- CDH1 -- PTEN -- STK11 |
| Summary |
Breast cancer is a recognized disease around the world with varying patient outcomes based on the type of breast cancer, access to healthcare and other factors. Survival rates for breast cancer are significantly lower in metastatic cases than localized cases. Early diagnosis and effective treatments for the efficient management of breast cancer are now in demand, as they help to prolong patient life. There have been many breakthrough developments in the molecular biology of breast cancer research in recent times. Advancements in diagnostic techniques (imaging and biomarker detection) for brea |
| Bibliography |
Includes bibliographical references |
| Notes |
Moderate Penetrance BC Genes or Biomarkers |
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Print version record |
| Subject |
Breast -- Cancer -- Research.
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Breast -- Cancer -- Research
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| Form |
Electronic book
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| Author |
Suman, Shankar
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Suman, Garima
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Mishra, Sanjay
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| ISBN |
9811451443 |
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9789811451447 |
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