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E-book

Title Novel therapies in head and neck cancer : beyond the horizon / edited by Maie A. St. John and No-Hee Park
Published London : Academic Press, 2020

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Description 1 online resource
Series Cancer sensitizing agents for chemotherapy ; v. 9
Cancer sensitizing agents for chemotherapy ; v. 9.
Contents Intro -- Novel Therapies in Head and Neck Cancer: Beyond the Horizon -- Copyright -- Cover Image Legend -- Aims and scope for series ̀̀Cancer sensitizing agents for chemotherapy ́́ -- About the Series Editor -- Aims and Scope of the Volume -- About the Volume Editors -- Maie A. St. John, M.D., Ph.D., FACS -- No-Hee Park, D.M.D., Ph.D. -- Preface -- It takes a village -- Contents -- Contributors -- Chapter 1: Introduction: Leaps and bounds -- Conflict of interest -- Introduction -- Surgical innovation: TORS and TLM -- Radiation therapy -- Immunotherapy -- Conclusion -- References
Chapter 2: Chemotherapy: Where we have been and where we are going -- Introduction -- Chemotherapy in locally advanced SCCHN -- Postoperative concurrent chemoradiotherapy -- Definitive combined chemoradiotherapy -- Definitive concurrent chemoradiotherapy (CCRT) -- Induction chemotherapy -- Sequential chemoradiotherapy -- Systemic therapy for recurrent, unresectable, or metastatic disease -- Nasopharyngeal cancer -- Conclusion -- References -- Chapter 3: Targeted therapy: Precision comes to life -- Introduction
Employing the precision medicine model for the management of head and neck squamous cell carcinoma -- Targeting the epidermal growth factor receptor -- Targeting the phosphoinositide 3-kinase-AKT-Mammalian target of rapamycin axis -- Single agent and combinatorial approaches to targeting the cell cycle pathway -- Precision medicine initiatives for the management of salivary gland carcinomas -- Leveraging the epigenetic and immunogenic role of histone deacetylase inhibitors -- Employing a multitargeted approach to tyrosine kinase inhibition -- Concluding remarks -- References
Chapter 4: Novel drug delivery systems for head and neck cancers: Beyond the horizon -- Introduction -- Polymer films -- Hydrogels and scaffolds -- Augmented radiation therapy and imaging -- Microneedle patches -- Nanoparticles -- Immunomodulation -- Conclusion -- Acknowledgments -- References -- Chapter 5: HPV-positive oropharyngeal cancers: Today and tomorrow -- Introduction -- Epidemiology -- Current staging -- Treatment options and outcomes -- Nonsurgical treatment options -- Radiation therapy -- Systemic therapy with radiation therapy -- Surgical treatment options
Transoral robotic surgery (TORS) -- Current status of deescalation strategies -- Minimally invasive surgery -- Replacing cisplatin with cetuximab -- Induction chemotherapy followed by reduced radiotherapy dose -- Immunotherapy -- Preventive strategies -- Ongoing and future research -- Conclusions -- References -- Chapter 6: Treatment resistance and a glimmer of hope, the promise of new agents -- Introduction -- Treatment resistance: Defining the problem -- Treatment resistance: Detecting the problem -- Biology is destiny -- Radiation resistance
Notes Includes index
Subject Head -- Cancer -- Treatment
Neck -- Cancer -- Treatment
Head and Neck Neoplasms -- therapy
Head -- Cancer -- Treatment
Neck -- Cancer -- Treatment
Form Electronic book
Author St. John, Maie A
Park, No-Hee
ISBN 9780128209295
0128209291