| Description |
1 online resource (347 p.) |
| Contents |
Front Cover -- Antimicrobial Peptides -- Copyright Page -- Contents -- List of contributors -- Preface -- 1 Historical developments of antimicrobial peptide research -- 1.1 Introduction -- 1.2 History and development of antimicrobial peptides -- 1.3 Antimicrobial peptides as host innate defense barricade -- 1.4 Peptide-based database: barn house for AMPs -- 1.5 Current timeline of antimicrobial peptide approvals -- 1.6 Chemical developments in AMPs -- 1.7 Antimicrobial peptides modification for medical application -- 1.8 Antimicrobial peptides modification for industrial applications |
|
1.9 An interdisciplinary upgrade to AMPs -- 1.10 Conclusion -- References -- 2 Biosynthesis of peptide antibiotics and innate immunity -- 2.1 Introduction -- 2.2 Antimicrobial peptides in innate immunity -- 2.3 Biosynthesis of nonribosomal and ribosomal peptides -- 2.3.1 Nonribosomal peptides -- 2.3.2 Ribosomally synthesized and posttranslationally modified peptides -- 2.4 Summary and conclusion -- References -- 3 Antimicrobial peptides: features and modes of action -- 3.1 Introduction -- 3.2 Historical perspective -- 3.3 Features of antimicrobial peptides -- 3.3.1 Diversity |
|
3.5.4.4 Unusual amino acid containing ribosomally synthesized antimicrobial peptides -- 3.6 Relationship of structure with function -- 3.7 Modes of action -- 3.7.1 Membrane-mediated action -- 3.7.1.1 Barrel-stave model -- 3.7.1.2 Toroidal pore model -- 3.7.1.3 Carpet model -- 3.7.1.4 Detergent model -- 3.7.2 Membrane-independent/nonmembrane-disruptive mechanism -- 3.8 Multifaceted roles of antimicrobial peptides -- 3.8.1 Anticancer antimicrobial peptides -- 3.8.2 Wound-healing antimicrobial peptides -- 3.8.3 Antidiabetogenic peptides -- 3.8.4 Antiinflammatory and immunomodulatory peptides |
|
3.8.5 Spermicidal peptides -- 3.9 Limitations and challenges -- 3.9.1 Stability -- 3.9.2 Toxicity -- 3.9.3 Salt sensitivity -- 3.9.4 Aggregation propensity -- 3.10 Conclusion -- References -- 4 Purification and characterization of antimicrobial peptides -- 4.1 Purification techniques -- 4.1.1 Solid-phase extraction on C18 column -- 4.1.2 Ion-exchange chromatography -- 4.1.3 Gel permeation chromatography -- 4.1.4 Affinity chromatography -- 4.1.5 Membrane filtration -- 4.1.6 High-performance liquid chromatography -- 4.1.6.1 High-performance gel permeation chromatography |
| Notes |
Description based upon print version of record |
|
4.1.6.2 Cation-exchange high-performance liquid chromatography |
| Form |
Electronic book
|
| Author |
Sreejith, K
|
| ISBN |
9780323903202 |
|
0323903207 |
|
