| Description |
1 online resource |
| Series |
Issues in toxicology ; 29 |
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Issues in toxicology ; 29.
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| Contents |
Cover; Contents; Chapter 1 Addressing Challenges to Progress in Human Stem Cell Toxicology Concepts and Practice; 1.1 Filling in the Stem Cell Gap in Human Toxicology; 1.2 Historical Impact of the Hierarchical, Anatomical, Sub-disciplinary Structure of Toxicological Sciences; 1.3 Human Stem Cell Toxicology as a Stem Cell Exact Science; 1.4 Health and Medical Applications for Human Stem Cell Toxicological Sciences; 1.5 Introducing the Future Diverse Impacts of Human Stem Cell Toxicology; Acknowledgments; References; Chapter 2 Alternative Methods in Haematopoietic Stem Cell Toxicology |
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2.1 Introduction2.2 Haematopoietic Stem Cell Toxicity or Hematotoxicity; 2.2.1 Sources of Haematopoietic Stem Cell Toxicity; 2.2.2 Importance of Studying Haematopoietic Stem Cell Toxicity; 2.2.3 Haematopoietic Stem Cell Toxicity in Drug Development; 2.3 Colonogenic Assays as Predictors of Haematopoietic Stem Cell Toxicity; 2.3.1 CFU-GM Colonogenic Assay; 2.3.2 CFU-Mk Colonogenic Assay; 2.3.3 BFU-E Colonogenic Assay; 2.3.4 Lymphoid Lineage Based Colonogenic Assays; 2.4 Conclusions; Acknowledgments; References; Chapter 3 High-throughput Screening of Toxic Chemicals on Neural Stem Cells |
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3.1 Neural Stem Cells3.2 Toxic Chemicals in the Environment; 3.3 Mechanisms of Neural Stem Cell Toxicity; 3.3.1 Ion Channel Blocking; 3.3.2 Drug Metabolism Effects; 3.3.3 Oxidative Stress; 3.3.4 DNA/RNA Denaturation; 3.3.5 Membrane Compromise; 3.3.6 Other Mechanisms of Neurotoxicity; 3.4 NSC Differentiation; 3.5 Conventional In vitro Assays for Toxicity Screening against Neural Stem Cells; 3.5.1 Well Plate Assays; 3.5.2 Cellular Microarray Assays; 3.5.3 Microfluidic Assays; 3.5.4 Other Assays; 3.6 Challenges of Conventional In vitro Approaches in Neurotoxicity Screening |
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3.7 Conclusions and Future DirectionsAcknowledgments; References; Chapter 4 The Role of Catecholamines in Stem Cell Mobilisation; 4.1 Introduction; 4.2 Catecholamines; 4.3 Catecholamines and Stem Cell Mobilisation; 4.3.1 Endothelial Progenitor Cells; 4.3.2 Mesenchymal Stem Cells; 4.3.3 Catecholamines and Stem Cell Biology; 4.4 Consequences of Catecholamine-modulating Agents for Stem Cell Toxicity; 4.4.1 Other Considerations; 4.5 Concluding Comments; References |
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Chapter 5 Toxicological Risk Assessment -- Proposed Assay Platform Using Stem and Progenitor Cell Differentiation in Response to Environmental Toxicants5.1 Introduction; 5.1.1 Toxicity; 5.1.2 Environmental Toxicology; 5.1.3 Predictive Toxicology; 5.1.4 Automated High Content Imaging and High Throughput, or High Content, Screening; 5.1.5 Risk Assessment; 5.1.6 Components of Risk Assessment; 5.2 Environmental Toxicological Risk Assessment Employing an Assay Platform That Uses Stem and Progenitor Cell Differentiation; 5.2.1 Endothelial Colony Forming Cells (ECFCs) |
| Summary |
Toxicity against tissue stem cells (TSCs) is a major problem in drug development and environmental health science. Despite their essential function in all human cellular tissues, the nature of tissue stem cells is not fully understood. The small fraction of stem cells in tissues and the lack of specific biomarkers for their quantification present a formidable challenge to developing tools for their study and assays that can identify stem cell-toxic agents. Human Stem Cell Toxicology reveals TSC toxicity as a biomedical reality that is now well under siege by newly emerging ideas and technologies, despite these challenges. Chapters consider stem cell toxicity by environmental agents, pharmaceutical drug candidates, and marketed therapeutic medicines with adverse side effects. New insights to cellular, molecular, biochemical, and chemical mechanisms of human tissue stem cell toxicity are brought together. Experimental and theoretical treatments are of specific topics, including approaches to monitoring TSC function, newly discovered TSC types and TSC toxicity resistance mechanisms, are covered by expert authors. This book informs and champions the continued development of innovative technologies to predict the TSC toxicity of compounds before their use, whether in patients or the environment, by addressing emerging new cell-based approaches and concepts for technical innovation. This publication will be a useful reference for postgraduate students and researchers working in toxicology, pharmaceutical science, tissue cell biology and stem cell biology |
| Notes |
Online resource; title from PDF title page (Royal Society of Chemistry, viewed September 15, 2016) |
| Subject |
Stem cells.
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Drugs -- Side effects.
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Stem Cells -- drug effects
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Drug-Related Side Effects and Adverse Reactions
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Stem Cells
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Drugs -- Side effects
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Stem cells
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| Form |
Electronic book
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| Author |
Sherley, James L., editor.
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Anderson, Diana, editor.
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| ISBN |
9781782626787 |
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1782626786 |
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