Title (NAS Colloquium) Self-Perpetuating Structural States in Biology, Disease, and Genetics

Published Washington : National Academies Press, 2002

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Description 1 online resource (140 pages) Series Online access: NCBI NCBI Bookshelf Contents Self-Perpetuating Structural States in Biology, Disease, and Genetics -- Copyright -- Contents -- Colloquium Self-perpetuating structural states in biology, disease, and genetics -- Colloquium Transmission of prions -- “NATURALâ€? TRANSMISSION OF PRIONS -- IATROGENIC TRANSMISSION OF PRIONS -- EXPERIMENTAL TRANSMISSION OF SURFACE-BOUND PRIONS -- CONCLUDING REMARKS -- Colloquium Conservation of a portion of the S.cerevisiae Ure2p prion domain that interacts with the full-length protein -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION Colloquium Interactions among prions and prion “strainsâ€? in yeastMATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease byâ€? -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium Chaperoning brain degeneration -- MATERIALS AND METHODS -- A DROSOPHILA MODEL FOR HUMAN NEURODEGENERATIVE DISEASE -- THE MOLECULAR CHAPERONE HSP70 IS A POTENT SUPPRESSOR OF POLYGLUTAMINE PATHOGENICITY CHAPERONE SUPPRESSION OF Î?-SYNUCLEIN TOXICITY IN A DROSOPHILA MODEL FOR PARKINSON'S DISEASEENDOGENOUS CHAPERONE ACTIVITY PLAYS A ROLE IN -SYNUCLEIN TOXICITY IN DROSOPHILA AND POTENTIALLY ALSO IN PARKINSON'S DISEASE -- DISCUSSION -- Colloquium Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity -- MECHANISM OF POLYQ AGGREGATION -- RELATIONSHIP BETWEEN POLYQ AGGREGATION AND TOXICITY -- TRANSCRIPTIONAL DYSREGULATION BY POLYQ AGGREGATION -- ROLE OF MOLECULAR CHAPERONES IN POLYQ AGGREGATION AND TOXICITY ROLE OF THE UBIQUITIN-PROTEASOME SYSTEM IN POLYQ AGGREGATION AND TOXICITYPERSPECTIVES -- Colloquium Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- CONCLUSION -- Colloquium Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity -- METHODS -- RESULTS AND DISCUSSION -- Colloquium The insulation of genes from external enhancers and silencing chromatin -- AN INSULATOR AS AN ENHANCER-BLOCKING ELEMENT INSULATORS AS BARRIERSCONCLUSION -- Colloquium Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prionâ€? -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- Colloquium Heritable chromatin structure: Mapping “memoryâ€? in histones H3 and H4 -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION Notes ""Colloquium Does heterochromatin protein 1 always follow code?"" English Print version record Subject Biology -- Congresses Proteins -- Conformation -- Congresses Biology Proteins -- Conformation Genre/Form Conference papers and proceedings Form Electronic book ISBN 9780309570459 030957045X 0309084458 9780309084451

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