| Description |
1 online resource (746 pages) |
| Series |
Lung Biology in Health and Disease |
|
Lung biology in health and disease.
|
| Contents |
INTRODUCTION; PREFACE; CONTRIBUTORS; CONTENTS; Drug Development of Inhaled Steroids A Pharmacologist's View Based on Experiences from the Budesonide Project; How Inhaled Corticosteroids Changed Asthma Therapy; Side Effects of Inhaled Corticosteroids; Mechanisms of Gene Regulation by the Glucocorticoid Receptor; Relationship of Dose- and Time-Dependent Corticosteroid Responses to Receptor Turnover; Blockade of Chemokine Production /Function as an Example of Glucocorticoid Anti-in.ammatory Actions; Newly Recognized Glucocorticoid Targets; Aerosol Delivery Devices and Airways /Lung Deposition |
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Uptake, Retention, and Biotransformation of Corticosteroids in the Lung and AirwaysSystemic Disposition and Effects of Inhaled Corticosteroids; Extrapulmonary Effects of Inhaled Corticosteroids; Factors Involved in the Pulmonary Targeting of Inhaled Glucocorticoids; Reversible Glucocorticoid Esteri.cation; Airway Selectivity of Current Inhaled Corticosteroids in Properly Designed Studies; Childhood Asthma and Growth; Evaluation and Comparison of Inhaled Steroids |
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The Role of Direct Assessment of Airway In.ammation in Evaluating Inhaled Glucocorticosteroid Ef.cacy and in Managing the Asthmatic PatientUse of Exhaled Nitric Oxide as Readout for Inhaled Corticosteroid Ef.cacy; Markers of Systemic Actions of Corticosteroids; Patient Adherence to Inhaled Corticosteroid Therapy; Prospects for Developing Inhaled Steroids with Extrahepatic Metabolism "Soft Steroids"; Design and Development of a Soft Corticosteroid, Loteprednol Etabonate; Development of Inhaled Steroids Based Upon Prodrugs with Prolonged Intraluminal Retention Time |
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Transcription Factors AP-1 and NF-kB as Targets for Development of Anti-in.ammatory DrugsRemodeling and the Effects of Steroids in Asthma; Inhaled Corticosteroids and the Natural History of Asthma; Combination Therapies Using Inhaled Corticosteroids; AUTHOR INDEX; SUBJECT INDEX |
| Summary |
This book sums up the mechanistic basis, current status, and future prospects of steroid inhalation as the cornerstone of prophylactic asthma therapy, identifying its kinetic basis-especially the essential airway selectivity-and including a historical account of inhaled glucocorticoid development. Makes connections among the underlying pharmacology, impact of new simulation models, newly recognized molecular targets, and therapeutic outcomes of short- and long-term steroid inhalation therapy!Containing more than 1600 works cited, drawings, tables, equations, and micrographs, Inhaled Steroids in |
| Notes |
Print version record |
| Subject |
Asthma -- Chemotherapy.
|
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Glucocorticoids -- Therapeutic use
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Asthma -- Chemotherapy
|
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Glucocorticoids -- Therapeutic use
|
| Form |
Electronic book
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| ISBN |
9781135555689 |
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1135555680 |
|
