| Description |
1 online resource (342 pages) : color illustrations |
| Series |
Springer series in biophysics ; 16 |
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Springer series in biophysics ; 16.
|
| Contents |
Part I: Introduction -- From Physiology, Genomes, Systems, and Self-Organization to Systems Biology: The Historical Roots of a Twenty-First Century Approach to Complexity / M.A. Aon, D. Lloyd and V. Saks -- Complex Systems Biology of Networks: The Riddle and the Challenge / Miguel A. Aon -- Part II: Systems Biology of Signaling Networks -- The Control Analysis of Signal Transduction / Hans V. Westerhoff, Samrina Rehman, Fred C. Boogerd, Nilgun Yilmaz and Malkhey Verma -- MicroRNAs and Robustness in Biological Regulatory Networks. A Generic Approach with Applications at Different Levels: Physiologic, Metabolic, and Genetic / Jacques Demongeot, Olivier Cohen and Alexandra Henrion-Caude -- Dynamics of Mitochondrial Redox and Energy Networks: Insights from an Experimental-Computational Synergy / Sonia Cortassa and Miguel A. Aon -- Adenylate Kinase Isoform Network: A Major Hub in Cell Energetics and Metabolic Signaling / Song Zhang, Emirhan Nemutlu, Andre Terzic and Petras Dzeja -- Part III: Systems Biology of Cellular Structures and Fluxes -- Moonlighting Function of the Tubulin Cytoskeleton: Macromolecular Architectures in the Cytoplasm / Judit Ovádi and Vic Norris -- Metabolic Dissipative Structures / Ildefonso Mtz. de la Fuente -- Systems Biology Approaches to Cancer Energy Metabolism / Alvaro Marín-Hernández, Sayra Y. López-Ramírez, Juan Carlos Gallardo-Pérez [and 3 others] -- Part IV: Systems Biology of Organ Function -- Network Dynamics in Cardiac Electrophysiology / Zhilin Qu -- Systems Level Regulation of Cardiac Energy Fluxes Via Metabolic Cycles: Role of Creatine, Phosphotransfer Pathways, and AMPK Signaling / Valdur Saks, Uwe Schlattner, Malgorzata Tokarska-Schlattner, Theo Wallimann [and 7 others] -- Part V: Systems Biology of Microorganisms -- Temporal Partitioning of the Yeast Cellular Network / Douglas B. Murray, Cornelia Amariei, Kalesh Sasidharan, Rainer Machné, Miguel A. Aon and David Lloyd -- Systems Biology and Metabolic Engineering in Bacteria / Johannes Geiselmann |
| Summary |
Systems Biology represents a new paradigm aiming at a whole-organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component parts. The study of network properties, and how they control and regulate behavior from the cellular to organism level, constitutes a main focus of Systems Biology. This book addresses from a novel perspective a major unsolved biological problem: understanding how a cell works and what goes wrong in pathology. The task undertaken by the authors is in equal parts conceptual and methodological, integrative and analytical, experimental and theoretical, qualitative and quantitative, didactic and comprehensive. Essentially, they unravel the spatio-temporal unfolding of interacting mass-energy and information networks at the cellular and organ levels, as well as its modulation through activation or repression by signaling networks to produce a certain phenotype or (patho)physiological response. Starting with the historical roots, in thirteen chapters this work explores the Systems Biology of signaling networks, cellular structures and fluxes, organ and microorganism functions. In doing so, it establishes the basis of a 21st century approach to biological complexity |
| Analysis |
levenswetenschappen |
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life sciences |
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metabolomica |
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metabolomics |
|
systeembiologie |
|
systems biology |
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biofysica |
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biophysics |
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eiwitexpressieanalyse |
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proteomics |
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computertechnieken |
|
computer techniques |
|
Biology (General) |
|
Biologie (algemeen) |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Systems biology.
|
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Cellular signal transduction.
|
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Metabolic Networks and Pathways
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Signal Transduction
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Systems Biology
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Cellular signal transduction
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Systems biology
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| Form |
Electronic book
|
| Author |
Aon, M. A. (Miguel Antonio), editor.
|
|
Saks, V. A., editor
|
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Schlattner, Uwe, editor
|
| ISBN |
9783642385056 |
|
3642385052 |
|
3642385044 |
|
9783642385049 |
|
