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E-book

Title Osteoblasts : morphology, functions and clinical implications / Hugo Scheurer, editor
Published New York : Nova Science Publishers, [2013]
©2013

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Description 1 online resource
Series Cell biology research progress
Muscularsystem- anatomy, functions and injuries
Cell biology research progress.
Muscular system--anatomy, functions, and injuries series.
Contents Intro -- OSTEOBLASTS -- OSTEOBLASTS -- Contents -- Preface -- Osteoblasts under Mechanical Strain -- Abstract -- Abbreviations -- 1. Introduction -- 1.1. Bone Tissue Cellular Structure -- 1.2. Osteoblasts -- 1.2.1. Osteoblast Origin and Life Cycle -- 1.2.2. Osteoblast Function -- 1.2.3. Growth Factor and Hormone Effects on Osteoblasts -- 1.3. Runx2 Transcription Factor in Bone Biology -- 1.3.1. Runx2 in Osteoblast Differentiation -- 1.3.2. Structure of Runx2 Gene -- 1.3.3. Runx2 Expression -- 2. Bone Remodeling -- 2.1. Regulation of Bone Remodeling -- 2.2. The Role of the RANK / RANKL / OPG System in Bone Remodeling -- 2.3. Bone Remodeling Pathophysiology -- 3. Mechanotransduction -- 3.1. Bone Remodeling and Mechanotransduction -- 3.2. Runx2 in Mechanotransduction -- 3.3. Nuclear Factor Î#x9A;appa B (NF-κÎ#x92;) Transcription Factor in Mechanotransduction -- 3.4. Polycystins in Mechanotransduction -- 3.5. Model Systems for the Study of Mechanotransduction in Osteoblasts -- 3.6. The Role of Mechanotransduction in Bone Disease -- 3.7. Mechanical Stimulation as a Therapeutic Strategy against Bone Disease -- Conclusion -- References -- From Stem Cells to Osteoblast: Therapeutic Potential for Bone Tissue Engineering -- Abstract -- Introduction -- Mesenchymal Stem Cells -- Differentiation of MSC into Osteoblast -- Role of Growth Factors and Transcription Factors in Osteoblast Differentiation -- Role of Transcription Factor in Differentiation of Osteoblast -- Scaffolds -- Natural Scaffolds: Extracellular Matrix -- Glycosaminoglycans (GAGs) -- Chitosan Scaffold -- Tripolymer Scaffolds -- References -- Osteoblast Functions and their Role in Skeletal Bone Diseases -- Abstract -- Introduction -- Osteoblast Lineage and Differentiation -- Transcription Factors, Signaling Proteins and Osteoblast Differentiation -- Osteoblast Migration -- Osteoblasts and Bone Diseases
Osteoporosis -- Osteoarthritis -- Osteogenesis Imperfecta -- Van Buchem Disease and Sclerosteosis -- Oculodentodigital Dysplasia -- Camurati-Engelmann Disease -- Cleidocranial Dysplaysia -- Osteoblastic Bone Metastasis -- Acknowledgment -- References -- Osteoblast Differentiation and Related Diseases -- Abstract -- Introduction -- A. Transcription Factors Regulating Osteoblast Differentiation -- RUNX2 -- TWIST1 -- MSX1 and MSX2 -- SP7/Osterix -- β-Catenin -- ATF4 -- FoxO1 -- B. Diseases Associated with Osteogenic Transcription Factors -- Cleidocranial Dysplasia (CCD) -- Saethre Chotzen Syndrome (SCS) -- Boston-Type Craniosynostosis -- Non-Collagenous Osteogenesis Imperfecta Caused by SP7/OSX Mutation -- Coffin-Lowry Syndrome (CLS) -- Neurofibromatosis Type I -- Conclusion -- References -- BMP and Osteoblastogenesis Inhibitors -- Abstract -- Bone Morphogenetic Proteins -- BMP-Smad Signaling -- Extracellular Inhibitor -- Cytomembrane Inhibitors -- Intracellular Inhibitors -- Nuclear Inhibitors, Which Interact with Runx2 or Osx -- MicroRNAs -- Prospect for Future Therapy -- References -- The Effect of Molecular and Biochemical Differentiation Agentson Bone Formation -- Abstract -- Introduction -- Osteoblast Differentiation and Inducer Materials -- Standard Medium for Osteogenic Cultures -- Medium Supplements -- Ascorbic Acid -- 1. The Effect of Ascorobic Acid on Osteoclast Formation -- 2. The Effect of Ascorbic Acid on Osteoblast Formation -- B-Glycerophosphate (BGP) -- Dexamethasone (Dex) -- Vitamin D3 -- Bone Morphogenic Protein 2(BMP-2) -- Collagen I and Vetronectin -- Conclusion and Further Remarks -- References -- Evaluation of Characteristics of Osteoblasts and Factors Relatedto Osteoblastic Differentiation and Mineralization -- Abstract -- Introduction -- Characteristics of Osteblast -- Bone Morphogenetic Protein (BMP) -- Various Agents
Laboratory Experiments -- (1) Cellular Proliferation -- (2) Alkaline Phosphatase Activity Assays (ALP) -- (3) Mineralization Assay -- Conclusion -- References -- Index
Notes "Nova biomedical "--Cover
Bibliography Includes bibliographical references and index
Notes English
Description based on print version record
Subject Osteoclasts.
Bone resorption.
Bones -- Diseases.
Osteoclasts
Bone Resorption
Bone Diseases
MEDICAL -- Physiology.
SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
Bone resorption
Bones -- Diseases
Osteoclasts
Form Electronic book
Author Scheurer, Hugo
LC no. 2019716123
ISBN 9781624178078
1624178073