| Description |
1 online resource (xix, 370 pages) : illustrations |
| Contents |
Front Matter -- The Academia-Market Bouncing of Peptide Drugs : Challenges and Strategies in Translational Research with Peptide Drugs. Peptides as Leads for Drug Discovery / Paul J Edwards, Steven R LaPlante -- Marketing Antimicrobial Peptides: A Critical Academic Point of View / Eduard Bardaj̕ -- Oral Peptide Drug Delivery: Strategies to Overcome Challenges / Josias H Hamman, Jan H Steenekamp -- Rational Design of Amphipathic a-Helical and Cyclic [beta]- Sheet Antimicrobial Peptides: Specificity and Therapeutic Potential / Wendy J Hartsock, Robert S Hodges -- Conotoxin-Based Leads in Drug Design / Muharrem Akcan, David J Craik -- Plant Antimicrobial Peptides: From Basic Structures to Applied Research / Suzana M Ribeiro, Simoni C Dias, Octavio L Franco -- Peptide Drugs' Translational Tales : Peptide Drugs before, Through and after Industry Pipelines. Omiganan Pentahydrochloride: A Novel, Broad-Spectrum Antimicrobial Peptide for Topical Use / Evelina Rubinchik, Dominique Dugourd -- Turning Endogenous Peptides into New Analgesics: The Example of Kyotorphin Derivatives / Marta M B Ribeiro, Isa D Serrano, S̤nia S̀ Santos -- The Development of Romiplostim : A Therapeutic Peptibody Used to Stimulate Platelet Production / Graham Molineux, Ping Wei -- HIV vs. HIV: Turning HIV-Derived Peptides into Drugs / Henri G Franquelim, Pedro M Matos, A Salom̌ Veiga -- Sifuvirtide, A Novel HIV-1 Fusion Inhibitor / Xiaobin Zhang, Hao Wu, Fengshan Wang -- Whither Peptide Drugs? Peptides Shaping the Future of Drug Development. Endogenous Peptides and Their Receptors as Drug Discovery Targets for the Treatment of Metabolic Disease / Mary Ann Pelleymounter, Yuren Wang, Ning Lee -- Translation of Motilin and Ghrelin Receptor Agonists into Drugs for Gastrointestinal Disorders / Gareth J Sanger, John Broad, David H Alpers -- Of Mice and Men: Translational Research on Amylin Agonism / Jonathan D Roth, Christine M Mack, James L Trevaskis, David G Parkes -- Peptides and Polypeptides as Immunomodulators and Their Consequential Therapeutic Effect in Multiple Sclerosis and Other Autoimmune Diseases / Ruth Arnon, Michael Sela, Rina Aharoni -- Development of Antibody Fragments for Therapeutic Applications / Sofia Carte-Real, Frederico Aires da Silva, Joao Gonzalves -- Index |
| Summary |
Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the ""bench to bedside"" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, wh |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Print version record |
| Subject |
Peptide drugs.
|
|
Peptide drugs -- Case studies
|
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Drug development.
|
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Drug Discovery
|
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Peptides
|
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Translational Research, Biomedical
|
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MEDICAL -- Pharmacology.
|
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Drug development
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Peptide drugs
|
| Genre/Form |
Case studies
|
| Form |
Electronic book
|
| Author |
Castanho, Miguel A. R. B.
|
|
Santos, Nuno
|
| ISBN |
9783527636730 |
|
3527636730 |
|
9783527636754 |
|
3527636757 |
|
3527636749 |
|
9783527636747 |
|
1283302519 |
|
9781283302517 |
|
9786613302519 |
|
6613302511 |
|
