Description |
1 online resource (xii, 397 pages) : illustrations |
Series |
Contemporary clinical neuroscience |
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Contemporary clinical neuroscience.
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Contents |
History -- History and Overview of Orexin/Hypocretin Research -- Overview of the Orexin/Hypocretin Neuronal System -- Orexin and Orexin Receptors -- Orexin Projections and Localization of Orexin Receptors -- Neuronal Responses to Hypocretin/Orexin -- Afferent System of Orexin Neurons -- Assessment of Orexin/Hypocretin Functions in Tissue and Biological Fluids -- Hypocretin Measurements in the CSF, and Blood and Brain Tissue -- Hypocretin Receptor-Activated G Proteins Revealed by [35S]GTP?S Autoradiography -- Physiology -- Orexin System and Feeding Behavior -- Orexins and the Autonomic Nervous System -- Neuroendocrine Role of the Orexins (Hypocretins) -- The Orexin/Hypocretin System and Stress and Emotion -- Physiology -- Hypocretin as a Wakefulness Regulatory Peptide -- Hypocretin/Orexin Tonus and Vigilance Control -- Hypocretin System and Aminergic and Cholinergic Systems in the Control of Vigilance -- Orexin and Hypothalamic Control of Sleep and Waking -- Hypocretin/Orexin and Motor Function -- Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency -- Overview of Human Narcolepsy -- Canine Models of Narcolepsy -- Rodent Models of Human Narcolepsy-Cataplexy -- Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency -- Hypocretin Deficiency in Human Narcolepsy -- Hypocretin Status in Neurological Disorders in Relation to Excessive Sleepiness and Cataplexy -- Hypocretin Measures in Psychiatric Disorders -- Neuroendocrinology of Human Narcolepsy -- Narcolepsy and Autoimmunity -- Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency -- Pharmacology of Hypocretin/Orexin Peptides and Small Molecules -- Rescue of Narcoleptic Orexin Neuron-Ablated Mice by Ectopic Overexpression of Orexin Peptides -- Hypocretin/Orexin Replacement Therapy in Hypocretin/Orexin-Deficient Narcolepsy |
Summary |
This cutting-edge review of the orexin/hypocretin system sets the stage for advanced research on the pathological mechanisms underlying the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include assessment of functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible treatments and pharmacology. The a |
Analysis |
biomedische wetenschappen |
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biomedicine |
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neurowetenschap |
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neuroscience |
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Medicine (General) |
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Geneeskunde (algemeen) |
Bibliography |
Includes bibliographical references and index |
Notes |
Print version record |
Subject |
Orexins.
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Narcolepsy.
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Neuropeptides -- physiology
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Nerve Tissue Proteins -- physiology
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Narcolepsy
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Narcolepsy -- physiopathology
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Biomédecine.
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Sciences de la vie.
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Narcolepsy
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Orexins
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Form |
Electronic book
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Author |
Nishino, Seiji
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Sakurai, Takeshi
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ISBN |
1588294447 |
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9781588294449 |
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9781592599509 |
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1592599508 |
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