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Title Tumor dormancy, quiescence, and senescence. Volume 2, Aging, cancer, and noncancer pathologies / edited by M.A. Hayat
Published Dordrecht : Springer, [2014]
©2014
Table of Contents
pt. I Molecular Mechanisms 
1.Asymmetric Dimethylarginine Accelerates Cellular Senescence / Stefanie M. Bode-Boger3
2.Membrane-Derived Extracellular Vesicles from Endothelial Progenitor Cells Activate Angiogenesis / Giovanni Camussi17
3.Induction of P21-Dependent Senescence: Role of NAE Inhibitor MLN4924 / Lijun Jia27
4.Regulation of the Novel Senescence Pathway by SKP2 E3 Ligase / Hui-Kuan Lin33
5.Oncogene-Induced Senescence: Role of Mitochondrial Dysfunction / Gerardo Ferbeyre45
6.Interleukin-6 Induces Premature Senescence Involving Signal Transducer and Activator of Transcription 3 and Insulin-Like Growth Factor-Binding Protein 5 / Koichi Nakajima53
7.A Role for the Nuclear Lamina Shape in Cell Senescence and Aging / Vered Raz61
8.Upregulation of Alpha-2-Macroglobulin in Replicative Senescence / Tan Jun Tong71
9.Elevation of Ceramide in Senescence: Role of Sphingolipid Metabolism / Mark E. Venable81
10.Molecular Signals Underlying Hair Follicle Morphogenesis and Cutaneous Regeneration / Yaojiong Wu89
11.Role of Chromatin-Remodeling Factor Jun Dimerization Protein 2 (JDP2) in Cellular Senescence / Kung-Kai Kuo101
12.Induction of Cellular Senescence: Role of Mitogen-Activated Protein Kinase-Interacting Kinase 1 / Naoko Shimada111
13.Mechanisms of Premature Cell Senescence / Michael S. Goligorsky121
pt. II Tumor and Cancer 
14.Nuclear Protein Pirin Negates the Cellular Senescence Barrier Against Cancer Development / Myriam Alcalay131
15.Defects in Chromatin Structure and Diseases / Gianfranco Peluso143
16.The Role of Fibrosis in Tumor Progression and the Dormant to Proliferative Switch / Jeffrey E. Green155
17.Diagnosis of Branchial Cyst Carcinoma: Role of Stem Cells and Dormancy / Athanassios Kyrgidis165
18.Function of the ING Proteins in Cancer and Senescence / Karl Riabowol179
19.Premalignancy and Cellular Senescence / Raya Saab195
20.Loss of Cdh1 Triggers Premature Senescence in Part via Activation of Both the RB/E2F1 and the CLASPIN/CHK1/P53 Tumor Suppressor Pathways / Wenyi Wei207
21.Suppression of Premature Senescence and Promotion of Metastatic Transformation: Role of Reduced TGF-Beta Signaling in Human Cancer Progression / Lu-Zhe Sun219
22.Senescence Escape in Melanoma: Role of Spleen Tyrosine Kinase SYK / Sophie Tartare-Deckert227
23.Micrometastatic Cancer Cells: Role of Tumor Dormancy in Non-small Cell Lung Cancer (NSCLC) / Harriet Wikman239
24.Quiescent CD4+ T Cells Inhibit Multiple Stages of HIV Infection / Dimitrios N. Vatakis253
pt. III Stem Cells and Cancer Stem Cells 
25.Senescent-Derived Pluripotent Stem Cells Are Able to Redifferentiate into Fully Rejuvenated Cells / Jean-Marc Lemaitre265
26.The Transcription Factor GATA2 Regulates Quiescence in Haematopoietic Stem and Progenitor Cells / Alex J. Tipping277
27.Dormancy and Recurrence of Cancer Stem Cells in Bone: Role of Bone Morphogenetic Proteins / Kounosuke Watabe289
28.Role of Microenvironment in Regulating Stem Cell and Tumor Initiating Cancer Cell Behavior and Its Potential Therapeutic Implications / Ana Krtolica301
 Index313

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Description 1 online resource (xxvii, 320 pages) : illustrations (some color)
Series Tumor dormancy and cellular quiescence and senescence ; volume 2
Tumor dormancy and cellular quiescence and senescence ; v. 2.
Contents Molecular Mechanisms -- Asymmetric Dimethylarginine Accelerates Cellular Senescence / Fotunato Scalera and Stefanie M. Bode-Böger -- Membrane-Derived Extracellular Vesicles from Endothelial Progenitor Cells Activate Angiogenesis / Vincenzo Cantaluppi, Federico Figliolini, Maria Chiara Deregibus and Giovanni Camussi -- Induction of P21-Dependent Senescence: Role of NAE Inhibitor MLN4924 / Yongfu Pan, Yi Sun and Lijun Jia -- Regulation of the Novel Senescence Pathway by SKP2 E3 Ligase / Guocan Wang, Yuan Gao, Li Chen, Ying-Jan Wang and Hui-Kuan Lin -- Oncogene-Induced Senescence: Role of Mitochondrial Dysfunction / Olga Moiseeva and Gerardo Ferbeyre -- Interleukin-6 Induces Premature Senescence Involving Signal Transducer and Activator of Transcription 3 and Insulin-Like Growth Factor-Binding Protein 5 / Hirotada Kojima, Hiroyuki Kunimoto, Toshiaki Inoue and Koichi Nakajima -- A Role for the Nuclear Lamina Shape in Cell Senescence and Aging / Christiaan H. Righolt and Vered Raz -- Upregulation of Alpha-2-Macroglobulin in Replicative Senescence / Li Wei Ma, Guo Dong Li and Tan Jun Tong -- Elevation of Ceramide in Senescence: Role of Sphingolipid Metabolism / Mark E. Venable -- Molecular Signals Underlying Hair Follicle Morphogenesis and Cutaneous Regeneration / Xusheng Wang and Yaojiong Wu -- Role of Chromatin-Remodeling Factor Jun Dimerization Protein 2 (JDP2) in Cellular Senescence / Kazunari K. Yokoyama and Kung-Kai Kuo -- Induction of Cellular Senescence: Role of Mitogen-Activated Protein Kinase-Interacting Kinase 1 / Samira Ziaei and Naoko Shimada -- Mechanisms of Premature Cell Senescence / Julien Maizel, Jun Chen and Michael S. Goligorsky -- Tumor and Cancer -- Nuclear Protein Pirin Negates the Cellular Senescence Barrier Against Cancer Development / Silvia Licciulli and Myriam Alcalay -- Defects in Chromatin Structure and Diseases / Umberto Galderisi and Gianfranco Peluso -- The Role of Fibrosis in Tumor Progression and the Dormant to Proliferative Switch / Lara H. El Touny, Dalit Barkan and Jeffrey E. Green -- Diagnosis of Branchial Cyst Carcinoma: Role of Stem Cells and Dormancy / Athanassios Kyrgidis -- Function of the ING Proteins in Cancer and Senescence / Uyen M. Tran, Uma Rajarajacholan and Karl Riabowol -- Premalignancy and Cellular Senescence / Hussein A. Abbas and Raya Saab -- Loss of Cdh1 Triggers Premature Senescence in Part via Activation of Both the RB/E2F1 and the CLASPIN/CHK1/P53 Tumor Suppressor Pathways / Shavali Shaik, Pengda Liu, Zhiwei Wang and Wenyi Wei -- Suppression of Premature Senescence and Promotion of Metastatic Transformation: Role of Reduced TGF-Beta Signaling in Human Cancer Progression / Shu Lin and Lu-Zhe Sun -- Senescence Escape in Melanoma: Role of Spleen Tyrosine Kinase SYK / Marcel Deckert and Sophie Tartare-Deckert -- Micrometastatic Cancer Cells: Role of Tumor Dormancy in Non-small Cell Lung Cancer (NSCLC) / Stefan Werner, Michaela Wrage and Harriet Wikman -- Quiescent CD4 + T Cells Inhibit Multiple Stages of HIV Infection / Jerome A. Zack and Dimitrios N. Vatakis -- Stem Cells and Cancer Stem Cells -- Senescent-Derived Pluripotent Stem Cells Are Able to Redifferentiate into Fully Rejuvenated Cells / Ollivier Milhavet and Jean-Marc Lemaitre -- The Transcription Factor GATA2 Regulates Quiescence in Haematopoietic Stem and Progenitor Cells / Neil P. Rodrigues and Alex J. Tipping -- Dormancy and Recurrence of Cancer Stem Cells in Bone: Role of Bone Morphogenetic Proteins / Sambad Sharma, Fei Xing and Kounosuke Watabe -- Role of Microenvironment in Regulating Stem Cell and Tumor Initiating Cancer Cell Behavior and Its Potential Therapeutic Implications / Ana Krtolica
Summary "In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases suchas breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M.A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that may remain dormant or may progress into a lethal form of cancer; the former are prevented from recruiting their own blood supply. Section I covers Molecular Mechanisms, with chapters on the role of NAE inhibitor MLN4924; oncogene-induced senescence; the role played by mitogen-activated protein kinase in the induction of cellular senescence; mechanisms of premature cell senescence and other topics. Section II examines Tumor and Cancer, discussing defects in chromatin structure and diseases; the role of fibrosis in tumor progression and the dormant to proliferative switch; the function of ING proteins in cancer and senescence and more. The final section is devoted to Stem Cells and Cancer Stem Cells, featuring chapters showing that senescent-derived pluripotent stem cells are able to redifferentiate into fully rejuvenated cells; that the transcription factor Gata2 regulates quiescence in haematopoietic stem and progenitor cells; and discussing dormancy and recurrence of cancer stem cells in bone. The contributors point out that the quiescent state regulates hematopoietic stem cells and muscle stem cells, and detail the role of kinase in the mediation of reversible quiescent state in a subset of ovarian, pancreatic, and colon cancers. Molecular mechanisms underlying stress-induced cellular senescence and accumulation of reactive oxygen species and induction of premature senescence are also presented. Discussion includes the important role of microRNAs in oxidative stress-induced apoptosis and senescence and the effect of microRNA as a modulator of cell proliferation in lung cancer. The book includes an explanation of the suppression of cellular senescence in glioblastoma brain tumor"--Publisher's description
Bibliography Includes bibliographical references and index
Notes Online resource; title from resource home page (ebrary, viewed March 18, 2016)
Subject Tumors.
Neoplasms -- physiopathology
Cellular Senescence -- physiology
Disease Progression
Neoplasm Metastasis -- physiopathology
Neoplasms
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Tumors
Form Electronic book
Author Hayat, M. A., 1940- editor.
ISBN 9789400777262
9400777264
Other Titles Aging, cancer, and noncancer pathologies