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Author Rushworth, Jo V., author

Title Impedimetric biosensors for medical applications : current progress and challenges / Jo V. Rushworth, Natalie A. Hirst, Jack A. Goode, Douglas J. Pike, Asif Ahmed, Paul A. Millner
Published New York, NY : ASME Press : Momentum Press, [2013]
Online access available from:
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Description 1 online resource (70 pages) : illustrations
Series Biomedical and nanomedical technologies
Biomedical & nanomedical technologies.
Contents 1. Introduction and scope
2. Biosensors -- 2.1 Brief history of biosensor development -- 2.2 Applications of biosensors -- 2.3 Biosensor architecture, an overview -- 2.4 Biorecognition element -- 2.5 Transducer element -- 2.6 Summary
3. Electrochemical impedance spectroscopy -- 3.1 Brief history of the development of impedimetric biosensors -- 3.2 An overview of impedance -- 3.3 Principles of impedimetric sensing -- 3.4 Presenting and analysing impedance data
4. Fabrication of impedimetric biosensors -- 4.1 Electrode design and materials -- 4.2 Bioreceptor tethering to transducer surfaces
5. Commercializing impedimetric biosensors: from laboratory to field -- 5.1 Components of a point-of-care diagnostic device -- 5.2 From research to point-of-care -- 5.3 Sample delivery & processing -- 5.4 Sensor regeneration -- 5.5 Barriers to commercialisation
6. Case studies of impedimetric biosensors for medical applications -- 6.1 Whole cells and pathogenic microorganisms -- 6.2 Protein and peptide biomarkers of disease -- 6.3 Small molecules
7. Conclusions and future perspectives
8. Author biographies -- References
Summary In this monograph, the authors discuss the current progress in the medical application of impedimetric biosensors, along with the key challenges in the field. First, a general overview of biosensor development, structure and function is presented, followed by a detailed discussion of impedimetric biosensors and the principles of electrochemical impedance spectroscopy. Next, the current state-of-the art in terms of the science and technology underpinning impedance-based biosensors is reviewed in detail. The layer- by-layer construction of impedimetric sensors is described, including the design of electrodes, their nano-modification, transducer surface functionalisation and the attachment of different bioreceptors. The current challenges of translating lab-based biosensor platforms into commercially-available devices that function with real patient samples at the POC are presented; this includes a consideration of systems integration, microfluidics and biosensor regeneration. The final section of this monograph describes case studies of successful impedance-based biosensors for the detection of a range of analytes from small molecules up to whole microorganisms. Finally, the authors put forward future perspectives for the clinical applications of impedimetric biosensors
Bibliography Includes bibliographical references (pages 57-70)
Notes Print version record
Subject Biosensors.
Impedance spectroscopy.
Biosensing Techniques.
Electric Impedance.
Form Electronic book
Author Ahmed, Asif, 1979- author
Goode, Jack A., author
Hirst, Natalie A., author
Millner, Paul A., author
Pike, Douglas J., author
ISBN 1606506366
1606506374 (electronic bk.)
9781606506370 (electronic bk.)