Description |
1 online resource (450 pages) |
Series |
Chapman & Hall/CRC Biostatistics Series |
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Chapman & Hall/CRC biostatistics series
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Contents |
1. What is a non-inferiority trial? -- 2. Non-inferiority trial considerations -- 3. Strength of evidence and reproducibility -- 4. Evaluating the active control effect -- 5. Across-trials analysis methods -- 6. Three-arm non-inferiority trials -- 7. Multiple comparisons -- 8. Missing data and analysis sets -- 9. Safety studies -- 10. Additional topics -- 11. Inference on proportions -- 12. Inferences on means and medians -- 13. Inference on time-to-event endpoints |
Summary |
The increased use of non-inferiority analysis has been accompanied by a proliferation of research on the design and analysis of non-inferiority studies. "Design and Analysis of Non-Inferiority Trials" brings together this body of research and confronts the issues involved in the design of a non-inferiority trial. Using examples from real clinical trials, the book discusses general and regulatory issues and illustrates how they affect analysis. Each chapter begins with a non-technical introduction, so the subject is easily understood by those without prior knowledge of non-inferiority |
Notes |
Print version record |
Subject |
Drugs -- Testing.
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Experimental design.
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Therapeutics, Experimental.
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Clinical Trials as Topic
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Research Design
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Drugs -- Testing
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Experimental design
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Therapeutics, Experimental
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Form |
Electronic book
|
ISBN |
9781584888055 |
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1584888059 |
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1283257645 |
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9781283257640 |
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