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Title Oxidative stress and antioxidants : their role in human disease / Ramon Rodrigo, editor
Published New York : Nova Biomedical Books, [2009]
Online access available from:
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Description 1 online resource (xiii, 358 pages) : illustrations
Contents Oxidative stress: basic overview / Joaquin Toro and Ramon Rodrigo -- Hypertension / Ramon Rodrigo -- Atherosclerosis / Victor Molina and Ramon Rodrigo -- Postoperative atrial fibrillation / Jose Vinay and Ramon Rodrigo -- Acute renal failure / Joaquin Toro, Victor Molina and Ramon Rodrigo -- Pre-eclampsia / Mauro Parra -- Metabolic syndrome / Rodrigo Castillo -- Diabetes Mellitus / Rodrigo Castillo -- Nonalcoholic steatohepatitis / Juan Gormaz and Ramon Rodrigo -- Neurodegenerative disorders / Rodrigo Pizarro -- Glaucoma / Leonidas Traipe, Rodrigo Castillo and Ramon Rodrigo
Summary "Oxidative stress is a relatively new concept that has been widely implicated in biomedical sciences during the last 20 years. It significantly participates in the pathophysiology of highly prevalent diseases such as diabetes, hypertension, preeclampsia, atherosclerosis, acute renal failure, Alzheimer and Parkinson diseases, among others. The metabolism of oxygen by cells generates potentially deleterious reactive oxygen species (ROS). Under normal conditions the rate and magnitude of oxidant formation is balanced by the rate of oxidant elimination However, an imbalance between pro-oxidants and antioxidants results in oxidative stress. Increased ROS levels in the cell have a substantial impact either leading to defective cellular function, aging, or disease. Therefore, a better understanding of the roles of ROS-mediated signaling in normal cellular function as well as in disease is necessary for developing therapeutic tools for oxidative stress-related pathologies. The potential beneficial role of antioxidants is discussed in the light of experimental studies, as well as clinical trials aimed to determine the outcome of patients. 'Oxidative Stress and Antioxidants: Their Role in Human Disease' is a practical guide for pathophysiology of oxidative stress and the latest therapeutic advances to modulate the antioxidant defense. This includes evidence from clinical trials, regarding the use of antioxidants and preconditioning, to protect the organism against ROS."--Publisher's description
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Antioxidants.
Oxidative stress.
Disease -- etiology.
Oxidative Stress.
Form Electronic book
Author Rodrigo, Ramon.
LC no. 2009013526
ISBN 1608765830 (electronic bk.)
9781608765836 (electronic bk.)