Description |
1 online resource (xiii, 358 pages) : illustrations |
Contents |
Oxidative stress: basic overview / Joaquin Toro and Ramon Rodrigo -- Hypertension / Ramon Rodrigo -- Atherosclerosis / Victor Molina and Ramon Rodrigo -- Postoperative atrial fibrillation / Jose Vinay and Ramon Rodrigo -- Acute renal failure / Joaquin Toro, Victor Molina and Ramon Rodrigo -- Pre-eclampsia / Mauro Parra -- Metabolic syndrome / Rodrigo Castillo -- Diabetes Mellitus / Rodrigo Castillo -- Nonalcoholic steatohepatitis / Juan Gormaz and Ramon Rodrigo -- Neurodegenerative disorders / Rodrigo Pizarro -- Glaucoma / Leonidas Traipe, Rodrigo Castillo and Ramon Rodrigo |
Summary |
"Oxidative stress is a relatively new concept that has been widely implicated in biomedical sciences during the last 20 years. It significantly participates in the pathophysiology of highly prevalent diseases such as diabetes, hypertension, preeclampsia, atherosclerosis, acute renal failure, Alzheimer and Parkinson diseases, among others. The metabolism of oxygen by cells generates potentially deleterious reactive oxygen species (ROS). Under normal conditions the rate and magnitude of oxidant formation is balanced by the rate of oxidant elimination However, an imbalance between pro-oxidants and antioxidants results in oxidative stress. Increased ROS levels in the cell have a substantial impact either leading to defective cellular function, aging, or disease. Therefore, a better understanding of the roles of ROS-mediated signaling in normal cellular function as well as in disease is necessary for developing therapeutic tools for oxidative stress-related pathologies. The potential beneficial role of antioxidants is discussed in the light of experimental studies, as well as clinical trials aimed to determine the outcome of patients. 'Oxidative Stress and Antioxidants: Their Role in Human Disease' is a practical guide for pathophysiology of oxidative stress and the latest therapeutic advances to modulate the antioxidant defense. This includes evidence from clinical trials, regarding the use of antioxidants and preconditioning, to protect the organism against ROS."--Publisher's description |
Bibliography |
Includes bibliographical references and index |
Notes |
Print version record |
Subject |
Oxidative stress.
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Antioxidants.
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Oxidative Stress
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Antioxidants
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Disease -- etiology
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antioxidant.
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MEDICAL -- Pathology.
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MEDICAL -- Pathophysiology.
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Antioxidants
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Oxidative stress
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Form |
Electronic book
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Author |
Rodrigo, Ramon
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LC no. |
2009013526 |
ISBN |
9781608765836 |
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1608765830 |
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