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Book Cover
E-book

Title Drug-drug interactions / edited by A. David Rodrigues
Edition 2nd ed
Published New York : Informa Healthcare, ©2008

Copies

Description 1 online resource (xi, 744 pages) : illustrations
Series Drugs and the pharmaceutical sciences ; 179
Drugs and the pharmaceutical sciences ; v. 179.
Contents Introducing pharmacokinetic and pharmacodynamic concepts / Malcolm Rowland -- In vitro enzyme kinetics applied to drug-metabolizing enzymes / Kenneth R. Korzekwa -- Human cytochromes P450 and their role in metabolism-based drug-drug interactions / Stephen E. Clarke and Barry C. Jones -- UDP-glucuronosyltransferases / Rory P. Remmel, Jin Zhou, and Upendra A. Argikar -- Drug-drug interactions involving the membrane transport process / Hiroyuki Kusuhara and Yuichi Sugiyama -- In vitro models for studying induction of cytochrome P450 enzymes / Jose M. Silva and Deborah A. Nicoll-Griffith -- In vitro approaches for studying the inhibition of drug-metabolizing enzymes and identifying the drug-metabolizing enzymes responsible for the metabolism of drugs (reaction phenotyping) with emphasis on cytochrome P450 / Brian W. Ogilvie [and others] -- The role of P-glycoprotein in drug disposition: significance to drug development / Matthew D. Troutman [and others] -- Cytochrome P450 protein modeling and ligand docking / K. Anton Feenstra, Chris de Graaf, and Nico P.E. Vermeulen -- Role of the gut mucosa in metabolically based drug-drug interactions / Kenneth E. Thummel, Danny D. Shen, and Nina Isoherannen -- Mechanism-based inhibition of human cytochromes P450: in vitro kinetics and in vitro-in vivo correlations / Xin Zhang, David R. Jones, and Stephen D. Hall -- Transporter-mediated drug interactions: molecular mechanisms and clinical implications / Jiunn H. Lin -- Metabolism and transport drug interaction database: a web-based research and analysis tool / Houda Hachad, Isabelle Ragueneau-Majlessi, and René H. Levy -- In vivo probes for studying induction and inhibition of cytochrome P450 enzymes in humans / Grant R. Wilkinson -- Drug-drug interactions: clinical perspective / David J. Greenblatt and Lisa L. von Moltke -- An integrated approach to assessing drug-drug interactions: a regulatory perspective / Shiew-Mei Huang, Lawrence J. Lesko, and Robert Temple -- Drug-drug interactions: toxicological perspectives / Sidney D. Nelson -- Drug-drug interactions: marketing perspectives / Kevin J. Petty and Jose M. Vega
Summary Helping researchers predict drug interactions in a more accurate and effective manner, this text covers every critical aspect of metabolism-based drug-drug interactions, including preclinical, clinical, toxicological, regulatory, and marketing perspectives by leaders in their respective fields
Bibliography Includes bibliographical references and index
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL
Print version record
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Subject Drug interactions.
Pharmacokinetics.
Drug Interactions
Drug Combinations
Pharmaceutical Preparations -- metabolism
Pharmacokinetics
MEDICAL -- Pharmacology.
Drug interactions.
Pharmacokinetics.
Form Electronic book
Author Rodrigues, A. David.
ISBN 9780849375941
0849375940
9780849375934
0849375932
9780429524301
0429524307