Description |
1 online resource (xi, 744 pages) : illustrations |
Series |
Drugs and the pharmaceutical sciences ; 179 |
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Drugs and the pharmaceutical sciences ; v. 179.
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Contents |
Introducing pharmacokinetic and pharmacodynamic concepts / Malcolm Rowland -- In vitro enzyme kinetics applied to drug-metabolizing enzymes / Kenneth R. Korzekwa -- Human cytochromes P450 and their role in metabolism-based drug-drug interactions / Stephen E. Clarke and Barry C. Jones -- UDP-glucuronosyltransferases / Rory P. Remmel, Jin Zhou, and Upendra A. Argikar -- Drug-drug interactions involving the membrane transport process / Hiroyuki Kusuhara and Yuichi Sugiyama -- In vitro models for studying induction of cytochrome P450 enzymes / Jose M. Silva and Deborah A. Nicoll-Griffith -- In vitro approaches for studying the inhibition of drug-metabolizing enzymes and identifying the drug-metabolizing enzymes responsible for the metabolism of drugs (reaction phenotyping) with emphasis on cytochrome P450 / Brian W. Ogilvie [and others] -- The role of P-glycoprotein in drug disposition: significance to drug development / Matthew D. Troutman [and others] -- Cytochrome P450 protein modeling and ligand docking / K. Anton Feenstra, Chris de Graaf, and Nico P.E. Vermeulen -- Role of the gut mucosa in metabolically based drug-drug interactions / Kenneth E. Thummel, Danny D. Shen, and Nina Isoherannen -- Mechanism-based inhibition of human cytochromes P450: in vitro kinetics and in vitro-in vivo correlations / Xin Zhang, David R. Jones, and Stephen D. Hall -- Transporter-mediated drug interactions: molecular mechanisms and clinical implications / Jiunn H. Lin -- Metabolism and transport drug interaction database: a web-based research and analysis tool / Houda Hachad, Isabelle Ragueneau-Majlessi, and René H. Levy -- In vivo probes for studying induction and inhibition of cytochrome P450 enzymes in humans / Grant R. Wilkinson -- Drug-drug interactions: clinical perspective / David J. Greenblatt and Lisa L. von Moltke -- An integrated approach to assessing drug-drug interactions: a regulatory perspective / Shiew-Mei Huang, Lawrence J. Lesko, and Robert Temple -- Drug-drug interactions: toxicological perspectives / Sidney D. Nelson -- Drug-drug interactions: marketing perspectives / Kevin J. Petty and Jose M. Vega |
Summary |
Helping researchers predict drug interactions in a more accurate and effective manner, this text covers every critical aspect of metabolism-based drug-drug interactions, including preclinical, clinical, toxicological, regulatory, and marketing perspectives by leaders in their respective fields |
Bibliography |
Includes bibliographical references and index |
Notes |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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Print version record |
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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL |
Subject |
Drug interactions.
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Pharmacokinetics.
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Drug Interactions
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Drug Combinations
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Pharmaceutical Preparations -- metabolism
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Pharmacokinetics
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MEDICAL -- Pharmacology.
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Drug interactions.
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Pharmacokinetics.
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Form |
Electronic book
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Author |
Rodrigues, A. David.
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ISBN |
9780849375941 |
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0849375940 |
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9780849375934 |
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0849375932 |
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9780429524301 |
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0429524307 |
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