| Description |
1 online resource (xxv, 568 pages) : illustrations |
| Contents |
Front Matter -- Deciphering DNA Sequence Information / Mark Kaganovich, Michael Snyder -- DNA Methylation / Carina Frauer, Fabio Spada, Heinrich Leonhardt -- Nucleosomes as Control Elements for Accessing the Genome / Mekonnen Lemma Dechassa, Karolin Luger -- Histone Modifications and Their Role as Epigenetic Marks / Karl Nightingale -- Chromatin Remodeling and Nucleosome Positioning / Gernot L̃ngst, Vladimir B Teif, Karsten Rippe -- The Folding of the Nucleosome Chain / Karsten Rippe -- The Crowded Environment of the Genome / Ron Hancock -- The Nuclear Lamina as a Chromatin Organizer / Nikolaj Zuleger, Eric C Schirmer -- Three-Dimensional Architecture of Genomes / Job Dekker -- Transcriptional Initiation: Frequency, Bursting, and Transcription Factories / Kieran Finan, Peter R Cook -- Processing of mRNA and Quality Control / Ute Schmidt, Edouard Bertrand -- The Nucleolus / Saskia Hutten, Belinda J Westman, Fraṅois-Michel Boisvert, Silvana van Koningsbruggen, Angus I Lamond -- Non-Coding RNAs as Regulators of Transcription and Genome Organization / Katalin Fejes T̤th, Gregory Hannon -- RNA Networks as Digital Control Circuits of Nuclear Functions / John S Mattick -- DNA Replication and Inheritance of Epigenetic States / Armelle Corpet, Genevïve Almouzni -- Interplay and Quality Control of DNA Damage Repair Mechanisms / Berina Eppink, Jeroen Essers, Roland Kanaar -- Higher Order Chromatin Organization and Dynamics / Hilmar Strickfaden, Thomas Cremer, Karsten Rippe -- The Mitotic Chromosome: Structure and Mechanics / John F Marko -- Meiotic Chromosome Dynamics / Nancy Kleckner, Liangran Zhang, Beth Weiner, Denise Zickler -- Understanding Genome Function: Quantitative Modeling of Chromatin Folding and Chromatin-Associated Processes / Mariliis Tark-Dame, Martijn S Luijsterburg, Dieter W Heermann, Roel van Driel -- Index |
| Summary |
By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gainedknowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription, replication, repair, recombination and chromosome segregation. A special emphasis is put on transcriptional control, including genome-wide interactions andnon-coding RNAs, chromatin structure, ep |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
| Subject |
Mammals -- Genetics
|
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Genomes.
|
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Molecular genetics.
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Genome -- physiology
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Genomics -- methods
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Cell Nucleus -- genetics
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Genome
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SCIENCE -- Life Sciences -- Genetics & Genomics.
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Genomes
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Mammals -- Genetics
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Molecular genetics
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| Form |
Electronic book
|
| Author |
Rippe, Karsten
|
| ISBN |
9783527640010 |
|
3527640010 |
|
9781283869904 |
|
128386990X |
|
