| Description |
1 online resource (xi, 535 pages) |
| Series |
Current topics in behavioral neurosciences ; volume 58 |
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Current topics in behavioral neurosciences ; 58.
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| Contents |
Intro -- Preface -- Contents -- Part I: Anhedonia -- History, Etiology, and Assessments -- Clinical and Preclinical Assessments of Anhedonia in Psychiatric Disorders -- 1 Introduction -- 2 Clinical Scales of Anhedonia and Reward Deficits: Beyond Pleasure and Interest -- 2.1 Early Measures (1970-2000) -- 2.2 Contemporary Measures (2001-2021) -- 2.3 Other Measures of Anhedonia -- 2.4 Gaps in Existing Anhedonia Clinical Scales -- 3 Preclinical and Clinical Reward Tasks -- 3.1 Anticipation -- 3.1.1 Preclinical -- 3.1.2 Clinical -- 3.2 Motivation and Effort Expenditure -- 3.2.1 Preclinical |
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3.2.2 Clinical -- 3.3 Valuation of Reward -- 3.3.1 Preclinical -- 3.3.2 Clinical -- 3.4 Expectation and Prediction Error -- 3.4.1 Preclinical -- 3.4.2 Clinical -- 3.5 Outcome and Consummatory Pleasure -- 3.5.1 Preclinical -- 3.5.2 Clinical -- 3.6 Reward Learning and Feedback Integration -- 3.6.1 Preclinical -- 3.6.2 Clinical -- 3.7 Translational Difficulties in Behavioral Assessments of Anhedonia -- 4 Conclusions -- References -- Developmental Trajectories of Anhedonia in Preclinical Models -- 1 The Concept of Anhedonia and Its Operationalization in Preclinical Models |
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1.1 Novel Tools for the Study of Anhedonia in Preclinical Models -- 1.2 The Reward Circuit and Its Study in Experimental Models -- 2 Anhedonia and Early-Life Adversity (ELA) -- 2.1 Why Study ELA and Anhedonia? The Human Landscape -- 2.2 What Is ELA and How Do We Model It? -- 2.3 Anhedonia Following ELA Involves a Developing Reward Circuit -- 2.4 Anhedonia After ELA: Manifestations and Sex Specificity -- 3 General Conclusions -- References -- Origins of Anhedonia in Childhood and Adolescence -- 1 Introduction -- 2 Impact of Positive Caregiving During Infancy |
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3 Impact of Memory Processes and Social Engagement During Early and Middle Childhood -- 4 Role of Self-Concept Development During Childhood and Adolescence on Anhedonia -- 5 Conclusions and Future Directions -- References -- Understanding Anhedonia from a Genomic Perspective -- 1 Introduction -- 2 Contemporary Psychiatric Genetics Frameworks: Relevance to RDoC -- 3 Genetic Studies of Anhedonia and Related Constructs -- 3.1 Twin and Family Studies -- 3.2 Candidate Gene Studies -- 3.3 GWAS -- 3.4 Polygenic Studies -- 4 Conclusions and Future Directions -- References |
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Environmental Contributions to Anhedonia -- 1 Introduction -- 2 Definitional Issues: Consummatory vs. Motivational Anhedonia -- 3 Definitional Issues: Stress Exposure and Response -- 4 Relation of Stress to Reward Processing in the Preclinical Literature -- 4.1 Chronic Mild Stress -- 4.2 Acute Stress -- 4.3 Social Stress -- 4.4 Maternal Separation -- 4.5 Stress Response and Reward -- 4.6 Summary -- 5 Relation of Stress to Reward Processing in Humans -- 5.1 Proximal Stressful Life Events -- 5.2 Early Adversity and Maltreatment -- 5.3 Acute Laboratory Stress -- 5.4 Stress Response and Reward |
| Summary |
Anhedonia is a key symptom (and often risk factor) for various neuropsychiatric disorders, including depression, schizophrenia, substance use disorders, post-traumatic stress disorders, and Parkinson's Disease, among others. Across disorders, anhedonia has been associated with worse disease course, including poor response to pharmacological, psychological and neurostimulation treatments as well as completed suicide. Mounting evidence emerging from preclinical and translational sciences has clarified that "anhedonia" can be parsed into partially independent subcomponents, including incentive motivation, consummatory pleasure, reward learning, and effort-based decision making, pointing to distinct neurobiological substrates that could underlie anhedonic phenotypes. Taking an integrative approach that emphasizes cross-species integration and dimensional conceptualization of mental illnesses (e.g., Research Domain Criteria (RDoC)), this book represents the most comprehensive evaluation, synthesis and integration of theories and empirical findings focused on anhedonia. Organized across five parts, the handbook starts with chapters on the history, etiology, and assessments of anhedonia (Part I), followed by a section on the role of anhedonia in psychiatric and neurological disorders (Part II). Using the RDoC Matrix as a guide, Part III presents chapters synthetizing preclinical and clinical findings on different reward processing subdomains (e.g., reward responsiveness, reward valuation, reward learning). Part IV is focused on selected special topics, including historical and current perspectives on the transdiagnostic nature and importance of social anhedonia, the role of inflammation in the pathophysiology of anhedonia, the use of computational modeling to "dissect" anhedonia and improve its understanding, and links between anhedonia and suicide. Finally, Part V includes chapters on pharmacological, psychological and neurostimulation treatments for anhedonia |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed August 19, 2022) |
| Subject |
Anhedonia.
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Anhedonia
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| Form |
Electronic book
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| Author |
Pizzagalli, Diego A., editor
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| ISBN |
9783031096839 |
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3031096835 |
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