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Title Models of seizures and epilepsy / Asla Pitkänen, Paul S. Buckmaster, Aristea S. Galanopoulou, Solomon L. Moshé
Edition Second edition
Published London, United Kingdom : Elsevier : Academic Press, [2017]
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Description 1 online resource (xxvi, 1151 pages)
Contents Cover; Title page; Copyright page; Contents; Contributors; Foreword; References; Preface; Part I -- Introduction; Chapter 1 -- What Can We Model?; Animal models of seizures; Animal models of epilepsy; A way forward; References; Chapter 2 -- Comparative Biology and Species Effects on Expression of Epilepsy; Introduction; How does epilepsy vary across species?; Conservative brain evolution; Vertebrate Phylogeny; Similarities Across Vertebrate Brains; Brain size; Brain Size Affects Circuitry; Mechanisms of brain evolution; Invasion; Loss of Connections; Parcellation; Ontogenetic Buffers
Axon DisplacementConcerted and Mosaic Brain Evolution; Tool for Comparing Developmental Stages Across Species; Evolution of the neocortex and hippocampus; Eversion of the Teleost Telencephalon; Amphibian Dorsal Pallium; Reptilian Dorsal Pallium; Dorsal Ventricular Ridge of Reptiles and Birds; Mammalian Neocortex; Pyramidal Cell Evolution; Neocortical Areas; Thalamus; Hippocampal Evolution; Epilepsy-Relevant Species-Specific Hippocampal Characteristics; Conclusions; Acknowledgments; References; Chapter 3 -- Strain Effects on Expression of Seizures and Epilepsy; Introduction
Dissection of genes that may underlie differences in expression of seizures or epilepsySignal-Recognition-Particle Assembly 9 (Srp9); Potassium Voltage-Gated Channel Subfamily J Member 10 (Kcnj10); Multiple PDZ Domain Crumbs Cell Polarity Complex Component (Mpdz); Cholinergic Receptor Genes; Conclusions; Acknowledgments; References; Further Reading; Chapter 4 -- Good Welfare Practice in Modeling Seizures and Epilepsy; General description; Background; Ethics and animal research; Legal Framework; NC3Rs report on welfare in rodent epilepsy models; Intrinsic features of epilepsy models; Seizures
Mouse strain effects on expression of seizures and epilepsyMouse Models of Acute Seizures and Seizure Susceptibility; Physically-Induced Seizures; Chemically-Induced Seizures; Antiseizure Drugs; The 6-Hz Psychomotor Seizure Model of Partial Epilepsy in Mice; Mouse Strain Differences in Occurrence of Spike-Wave Discharges; The Pilocarpine Model of Temporal Lobe Epilepsy in Mice; The Kainate Model of Temporal Lobe Epilepsy in Mice; The Intrahippocampal Kainate Model of Temporal Lobe Epilepsy in Mice; The Electrical Kindling Model of Temporal Lobe Epilepsy in Mice
The Flurothyl Kindling Mouse Model of Primary Generalized EpilepsiesThe Theiler's Virus Mouse Model of Encephalitis-Induced Temporal Lobe Epilepsy; Rat strain effects on expression of seizures and epilepsy; The Pilocarpine Model of Temporal Lobe Epilepsy in Rats; The Electrical Kindling Model of Temporal Lobe Epilepsy in Rats; Sustained Stimulation of the Basolateral Amygdala in Rats as a Model of Temporal Lobe Epilepsy; Rat Strain Differences in Occurrence of Spike-Wave Discharges or Other EEG Alterations
Bibliography Includes bibliographical references and index
Notes Vendor-supplied metadata
Subject Epilepsy -- Animal models.
Epilepsy.
Spasms.
Epilepsy.
Models, Animal.
Seizures.
Form Electronic book
Author Buckmaster, Paul S., editor
Galanopoulou, Aristea S., 1965- editor
Moshé, Solomon L., editor
Pitkänen, Asla, editor
ISBN 012804067X (electronic bk.)
9780128040676 (electronic bk.)