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Title Neuroblastoma : clinical and surgical management / Sabine Sarnacki, Luca Pio, editors
Published Cham, Switzerland : Springer, [2020]
Online access available from:
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Description 1 online resource (375 pages)
Contents Intro; Foreword; Contents; Part I: Epidemiology, Biology and Pathology Assessment; 1: Epidemiology; 1.1 Descriptive Epidemiology; 1.1.1 Incidence and Epidemiological Features; 1.1.2 Survival; 1.2 Etiology; 1.2.1 Perinatal Characteristics; Gestational Age, Birth Weight, and Size for Gestational Age; 1.2.2 Maternal Vitamin or Folic Acid Intake Around Pregnancy; 1.2.3 Breastfeeding; 1.2.4 Congenital Malformations; 1.2.5 Parental Smoking and Alcohol Consumption; 1.2.6 Pesticides Exposures; 1.2.7 Other Factors; References; 2: Biology of Neuroblastoma; 2.1 Introduction
2.2 Hereditary Genetic Factors2.2.1 Somatic Genetic Alterations; Copy-Number Alterations; Single-Gene Mutations; Expression Profiles; Spatial and Temporal Heterogeneity; References; 3: Neuroblastoma Pathogenesis; 3.1 Neuroblastoma, a Disease of the Neural Crest; 3.2 Key Genes Involved in Neuroblastoma Pathogenesis; 3.2.1 PHOX2B, a Transcription Factor Involved in Syndromic and Familial Neuroblastoma Cases; 3.2.2 MYCN, a Transcription Factor Associated with High-Risk Neuroblastoma
3.2.3 Implication of the ALK Tyrosine Kinase Receptor in Sporadic, Familial, and Syndromic Cases of Neuroblastoma3.2.4 Telomere Dysfunction Linked to TERT and ATRX Genomic Aberrations; 3.2.5 LIN28B; 3.3 Noncoding RNAs in Neuroblastoma Pathogenesis; 3.4 Metastasis Study in Neuroblastoma Models; 3.4.1 Orthotopic Xenografts in the Mouse; 3.4.2 LMO1; 3.4.3 SEMA3C; 3.5 Cell Identity and Plasticity in Neuroblastoma; References; 4: Neuroblastoma Pathology; 4.1 Introduction; 4.2 Historical Considerations; 4.3 Pathology Diagnosis; 4.3.1 Tumor Sampling/Handling
4.3.2 Differential Diagnosis4.4 International Neuroblastoma Pathology Classification (INPC); 4.4.1 Histological Categories and Subtypes; 4.4.2 Prognostic Grouping (Favorable Histology vs. Unfavorable Histology); 4.4.3 Age Factor in Neuroblastoma; 4.5 Bone Marrow Involvement in Neuroblastoma; 4.5.1 Sample Collection for Testing; 4.5.2 Trephine Biopsies; 4.5.3 Immunocytology (IC); 4.5.4 Quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR); 4.6 Tumor Progression in Neuroblastoma; 4.7 New Directions of Neuroblastoma Pathology Research
4.7.1 Potential "Actionable/Druggable" Targets in Neuroblastoma4.7.2 Molecular Targeting Therapies for Unfavorable Histology Neuroblastoma Resistant to the Current Therapy; 4.8 Conclusions; References; Part II: Imaging; 5: Radiology; 5.1 Introduction; 5.2 Imaging Modalities: Technical Aspects and Rational for Use; 5.2.1 Plain Films; 5.2.2 Ultrasonography; 5.2.3 Computed Tomography; 5.2.4 Magnetic Resonance Imaging; 5.2.5 Nuclear Medicine; 5.2.6 DICOM Data Storage; 5.3 Diagnostic Imaging at Diagnosis; 5.3.1 Classical Imaging Patterns; 5.3.2 Specific Diagnostic Issues
Summary This book addresses neuroblastoma, a type of embryonic tumor derived from neural crest cells and one of the most frequent extra-cranial solid tumors in children. However, the term also describes a heterogeneous group of tumors, the prognosis of which can differ greatly according to age, stage and biology. Some forms undergo spontaneous regression, and some are cured by surgery alone or after chemo-reduction, while others exhibit extremely aggressive behavior. Their successful treatment is one of the best examples of tailored medicine, which involves close collaboration between pediatric surgeons, pediatric oncologists, radiologists, nuclear medicine specialists, biologists, oncogeneticists and radiotherapists. The book pursues a unique approach, as it combines most essential insights from all of these fields, together with key information regarding epidemiology, physiopathology and palliative care. The respective chapters were written by the leading international experts on neuroblastoma, and present the latest advances in terms of research, surgical approaches and medical treatments. The book offers an invaluable resource to all pediatric surgeons, pediatricians, oncologists, students, researchers and all others involved in neuroblastoma management who want to benefit from their colleagues' expertise
Notes Differential Diagnosis of Retroperitoneal Solid Tumours During Childhood
Bibliography Includes bibliographical references
Notes Print version record
Subject Neuroblastoma -- Treatment
Form Electronic book
Author Pio, Luca, editor.
Sarnacki, Sabine, editor.
ISBN 3030183963