| Description |
xxii, 195 pages : color illustrations ; 28 cm |
| Series |
Primers in biology |
|
Primers in biology.
|
| Contents |
Ch. 1. From Sequence to Structure -- 1-0. Overview: Protein Function and Architecture -- 1-1. Amino Acids -- 1-2. Genes and Proteins -- 1-3. The Peptide Bond -- 1-4. Bonds that Stabilize Folded Proteins -- 1-5. Importance and Determinants of Secondary Structure -- 1-6. Properties of the Alpha Helix -- 1-7. Properties of the Beta Sheet -- 1-8. Prediction of Secondary Structure -- 1-9. Folding -- 1-10. Tertiary Structure -- 1-11. Membrane Protein Structure -- 1-12. Protein Stability: Weak Interactions and Flexibility -- 1-13. Protein Stability: Post-Translational Modifications -- 1-14. The Protein Domain -- 1-15. The Universe of Protein Structures -- 1-16. Protein Motifs -- 1-17. Alpha Domains and Beta Domains -- 1-18. Alpha/Beta, Alpha+Beta and Cross-Linked Domains -- 1-19. Quaternary Structure: General Principles -- 1-20. Quaternary Structure: Intermolecular Interfaces -- 1-21. Quaternary Structure: Geometry -- 1-22. Protein Flexibility -- Ch. 2. From Structure to Function -- 2-0. Overview: The Structural Basis of Protein Function -- 2-1. Recognition, Complementarity and Active Sites -- 2-2. Flexibility and Protein Function -- 2-3. Location of Binding Sites -- 2-4. Nature of Binding Sites -- 2-5. Functional Properties of Structural Proteins -- 2-6. Catalysis: Overview -- 2-7. Active-Site Geometry -- 2-8. Proximity and Ground-State Destabilization -- 2-9. Stabilization of Transition States and Exclusion of Water -- 2-10. Redox Reactions -- 2-11. Addition/Elimination, Hydrolysis and Decarboxylation -- 2-12. Active-Site Chemistry -- 2-13. Cofactors -- 2-14. Multi-Step Reactions -- 2-15. Multifunctional Enzymes -- 2-16. Multifunctional Enzymes with Tunnels -- Ch. 3. Control of Protein Function -- 3-0. Overview: Mechanisms of Regulation -- 3-1. Protein Interaction Domains -- 3-2. Regulation by Location -- 3-3. Control by pH and Redox Environment -- 3-4. Effector Ligands: Competitive Binding and Cooperativity -- 3-5. Effector Ligands: Conformational Change and Allostery -- 3-6. Protein Switches Based on Nucleotide Hydrolysis -- 3-7. GTPase Switches: Small Signaling G proteins -- 3-8. GTPase Switches: Signal Relay by Heterotrimeric GTPases -- 3-9. GTPase Switches: Protein Synthesis -- 3-10. Motor Protein Switches -- 3-11. Regulation by Degradation -- 3-12. Control of Protein Function by Phosphorylation -- 3-13. Regulation of Signaling Protein Kinases: Activation Mechanism -- 3-14. Regulation of Signaling Protein Kinases: Cdk Activation -- 3-15. Two-Component Signaling Systems in Bacteria -- 3-16. Control by Proteolysis: Activation of Precursors -- 3-17. Protein Splicing: Autoproteolysis by Inteins -- 3-18. Glycosylation -- 3-19. Protein Targeting by Lipid Modifications -- 3-20. Methylation, N-acetylation, Sumoylation and Nitrosylation -- Ch. 4. From Sequence to Function: Case Studies in Structural and Functional Genomics -- 4-0. Overview: From Sequence to Function in the Age of Genomics -- 4-1. Sequence Alignment and Comparison -- 4-2. Protein Profiling -- 4-3. Deriving Function from Sequence -- 4-4. Experimental Tools for Probing Protein Function -- 4-5. Divergent and Convergent Evolution -- 4-6. Structure from Sequence: Homology Modeling -- 4-7. Structure From Sequence: Profile-Based Threading and "Rosetta" -- 4-8. Deducing Function from Structure: Protein Superfamilies -- 4-9. Strategies for Identifying Binding Sites -- 4-10. Strategies for Identifying Catalytic Residues -- 4-11. TIM Barrels: One Structure with Diverse Functions -- 4-12. PLP Enzymes: Diverse Structures with One Function -- 4-13. Moonlighting: Proteins With More Than One Function -- 4-14. Chameleon Sequences: One Sequence with More than One Fold -- 4-15. Prions, Amyloids and Serpins: Metastable Protein Folds -- 4-16. Functions for Uncharacterized Genes: Galactonate Dehydratase -- 4-17. Starting From Scratch: A Gene Product of Unknown Function -- Ch. 5. Structure Determination -- 5-1. The Interpretation of Structural Information -- 5-2. Structure Determination by X-Ray Crystallography and NMR -- 5-3. Quality and Representation of Crystal and NMR Structures |
| Notes |
Formerly CIP. Uk |
| Bibliography |
Includes bibliographical references (pages 181-188) and index |
| Subject |
Proteins.
|
|
Proteins -- Structure.
|
|
Proteins -- Conformation.
|
|
Proteins -- physiology.
|
|
Protein Conformation.
|
| Author |
Ringe, Dagmar.
|
| LC no. |
2004351320 |
| ISBN |
0953918149 New Science Press |
|
1405119225 Blackwell paperback |
|
0878936637 Sinauer Associates paperback |
|
