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Title Cardiovascular and metabolic disease : scientific discoveries and new therapies / [editors] Philip Peplow, James Adams, Tim Young
Published [Cambridge] : Royal Society of Chemistry, 2015

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Description 1 online resource
Series RSC drug discovery ; 45
RSC drug discovery series ; 45.
Contents 880-01 Cover; Contents; Introduction; Chapter 1 The Relevance of Biomarkers, Risk Factors and Gene-Environment Interactions in Disease: Scientific Developments and Therapeutic Approaches; 1.1 Introduction; 1.2 Biomarkers of Disease; 1.3 Risk Factors of Disease; 1.4 Gene-Environment Interactions in Disease; 1.5 Drug Development and Targeted Therapies; 1.6 Conclusion; References; Part 1 Obesity; Chapter 2 Molecular Links between Obesity, Hypertension and Metabolic Dysfunction; 2.1 Introduction; 2.2 Consequences of Obesity on Cardiovascular and Metabolic Disease
880-01/(S 3.3 Adiposity and Adipose Tissue3.3.1 White, Brown and Beige Adipose Tissue; 3.3.2 Abdominal Body Fat Distribution Patterns; 3.3.3 Subcutaneous versus Visceral Adipose Tissue; 3.3.4 White Adipose Tissue Function and Adipocyte Size; 3.4 Adipokines; 3.4.1 Leptin; 3.4.2 Adiponectin; 3.5 Inflammation; 3.5.1 TNF-α ; 3.5.2 IL-6; 3.5.3 CRP; 3.6 Omics/Novel Biomarkers of Obesity and Risk of Further Metabolic Disease; 3.7 Conclusions; References; Chapter 4 Risk Factors for Obesity; 4.1 Introduction; 4.2 Obesity Can be Caused by Genetic and Other Diseases; 4.3 Obesity Can be Caused by Drugs
2.3 Role of the SNS in Obesity-related Hypertension2.4 Contribution of Leptin and Insulin to Obesity-related Hypertension; 2.5 Role of Pro-opiomelanocortin Neurons; 2.6 Contribution of Neuropeptide Y; 2.7 Contribution of Ghrelin; 2.8 Effects of Obesity Across Generations; 2.9 The Influence of Aversive Stress on Obesity-related Hypertension; 2.10 Conclusions; References; Chapter 3 Discovery of Biomarkers of Obesity; 3.1 Introduction; 3.2 Identifying and Classifying Obese Individuals; 3.2.1 Classifying Obesity in Adults; 3.2.2 Classifying Obesity in Infants and Children
4.4 The High Fat Food Problem4.5 Why is Dietary Fat a Problem?; 4.6 Alcohol is the Worst Obesogen; 4.7 Fad Foods and Obesity; 4.8 Toxic Fats; 4.9 Bad Carbohydrates, Empty Calories and High Glycemic Index; 4.10 Childhood Obesity; 4.11 Sedentary Lifestyles; 4.12 Why is Exercise so Important?; 4.13 Present Lessons for the Future; References; Chapter 5 Gene-Environment Interactions in Obesity; 5.1 Introduction; 5.2 Definition and Methods Used in the Assessment of Obesity; 5.3 Genetics and Obesity; 5.4 Animal Models and the Genetics of Obesity; 5.4.1 Spontaneous Animal Models of Obesity
5.4.2 Genetically Engineered Animal Models of Obesity5.5 Genetic Approaches to Studying Human Obesity; 5.6 Epigenetics and Obesity; 5.7 Environmental Genetic Interactions in Obesity; 5.8 Summary; References; Chapter 6 New Drug Design and Therapeutic Development for Weight Reduction: Preclinical Studies and Clinical Trials; 6.1 Obesity and its Metabolic Consequences; 6.1.1 The Strategic and Commercial Landscape of Drug Intervention; 6.2 Preclinical Studies; 6.2.1 CNS Approaches; 6.2.2 Peripheral Approaches; 6.3 Clinical Studies; 6.3.1 Lorcaserin; 6.3.2 Phentermine
Summary Cardiovascular and metabolic diseases remain the number one cause of death in developed countries and their prevalence is increasing rapidly in developing nations. This book brings together the recent information on these disorders and the links that exist between them in order to provide a complete picture of drug discovery for these conditions. The main three sections comprehensively discuss obesity, hypertension and cardiovascular disease, and diabetes in turn, following an introduction to the molecular links between them. The final chapter provides perspectives on future directions of the field. Chapters are contributed by leaders in the field from academia and industry and cover biomarkers, risk factors, gene-environment interactions, therapies and the various types of animal models that have been used to study each disease. Case studies describing the implementation of animal models in drug development further enhance the book's usefulness as a comprehensive guide to this important therapeutic area. Providing a full picture of the various types of animal models that have been used to study obesity, hypertension, and insulin resistance with recent case studies, this book provides a valuable resource for medicinal chemists and clinicians working in these disease areas
Notes Includes index
English
Online resource; title from PDF title page (Royal Society of Chemistry, viewed August 17, 2015)
Subject Cardiovascular system -- Diseases.
Metabolism -- Disorders.
Cardiovascular system -- Diseases -- Treatment.
Metabolism -- Disorders -- Treatment
Diseases.
Causation.
Insulin resistance.
Risk.
Probabilities.
Pharmaceutical chemistry.
Insulin shock.
Statistics.
Chemistry.
Pharmacology.
Public health.
Life sciences.
Physical sciences.
Medical care.
Drugs -- Design.
Metabolic syndrome.
Disease
Metabolic Diseases
Causality
Drug Discovery
Insulin Resistance
Risk
Epidemiologic Factors
Probability
Investigative Techniques
Chemistry, Pharmaceutical
Nutritional and Metabolic Diseases
Hyperinsulinism
Statistics as Topic
Chemistry
Pharmacology
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Quality of Health Care
Public Health
Glucose Metabolism Disorders
Biological Science Disciplines
Health Care Evaluation Mechanisms
Health Care Quality, Access, and Evaluation
Epidemiologic Methods
Natural Science Disciplines
Environment and Public Health
Delivery of Health Care
Disciplines and Occupations
Drug Design
Risk Factors
Metabolic Syndrome
Cardiovascular Diseases
Patient Care
probability.
chemistry.
pharmacology.
public health.
biological sciences.
physical sciences.
statistics.
Diseases & disorders.
Pharmacology.
MEDICAL -- Pharmacology.
SCIENCE -- Life Sciences -- Biochemistry.
Statistics
Risk
Public health
Probabilities
Physical sciences
Pharmacology
Pharmaceutical chemistry
Metabolic syndrome
Medical care
Life sciences
Insulin shock
Insulin resistance
Drugs -- Design
Diseases
Chemistry
Causation
Cardiovascular system -- Diseases
Cardiovascular system -- Diseases -- Treatment
Metabolism -- Disorders
Metabolism -- Disorders -- Treatment
Form Electronic book
Author Peplow, Philip, editor
Adams, James, editor
Young, Tim, editor
Royal Society of Chemistry (Great Britain)
ISBN 9781782622390
178262239X
9781782625247
1782625240
178262046X
9781782620464