| Description |
1 online resource (xiv, 402 pages, 16 unnumbered pages of plates) : illustrations (some color) |
| Series |
London Mathematical Society student texts ; 75 |
|
London Mathematical Society student texts ; 75.
|
| Contents |
Phage display systems for protein engineering / Andreas Ernst and Sachdev S. Sidhu -- Cell surface display systems for protein engineering / Sarah J. Moore [and others] -- Cell-free display systems for protein engineering / Pamela A. Barendt and Casim A. Sarkar -- Library construction for protein engineering / Daša Lipovšek [and others] -- Design and engineering of synthetic binding proteins using nonantibody scaffolds / Shohei Koide -- Combinatorial enzyme engineering / Patrick C. Cirino and Christopher S. Frei -- Engineering of therapeutic proteins / Fei Wen, Sheryl B. Rubin-Pitel, and Huimin Zhao -- Protein engineered biomaterials / Cheryl Wong Po Foo and Sarah C. Heilshorn -- Protein engineering using noncanonical amino acids / Deniz Yüksel [and others] -- Computer graphics, homology modeling, and bioinformatics / David F. Green -- Knowledge-based protein design / Michael A. Fisher [and others] -- Molecular force fields / Patrice Koehl -- Rotamer libraries for molecular modeling and design of proteins / Hidetoshi Kono -- Search algorithms / Julia M. Shifman and Menachem Fromer -- Modulating protein structure / M.S. Hanes, T.M. Handel, and A.B. Chowdry -- Modulation of intrinsic properties by computational design / Vikas Nanda, Fei Xu, and Daniel Hsieh -- Modulating protein interactions by rational and computational design / Jonathan S. Marvin and Loren L. Looger -- Future challenges of computational protein design / Eun Jung Choi, Gurkan Guntas, and Brian Kuhlman |
| Summary |
"Experimental protein engineering and computational protein design are broad but complementary strategies for developing proteins with altered or novel structural properties and biological functions. By describing cutting-edge advances in both of these fields, Protein Engineering and Design aims to cultivate a synergistic approach to protein science. The first half of the book discusses experimental approaches to protein engineering and starts by describing several high-throughput screening platforms for protein engineering. Key techniques used for diversity generation are also discussed. The next few chapters present examples of therapeutics, enzymes, biomaterials, and other proteins that have been engineered by rational or combinatorial approaches. The section finishes with a chapter on the use of non-natural amino acids in protein engineering. The second half of the book introduces computational protein design, beginning with a chapter on computational and informatics algorithms used in protein engineering. Core components of computational protein design are then discussed in detail, and examples of heuristic protein design are provided. Subsequent chapters present examples of how computational design has played a critical role in advancing the field of protein engineering. Concluding with a chapter outlining current challenges in the field, this book makes computational protein design and diversity-oriented protein engineering widely accessible to a broad audience in academia and industry alike."--Publisher's description |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Print version record |
| Subject |
Protein engineering.
|
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Protein Engineering
|
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Models, Molecular
|
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Proteins -- chemistry
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SCIENCE -- Biotechnology.
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Protein engineering
|
| Form |
Electronic book
|
| Author |
Park, Sheldon J
|
|
Cochran, Jennifer R
|
| ISBN |
9781420076592 |
|
1420076590 |
|
9780429191633 |
|
0429191634 |
|
