Title New vaccine development : establishing priorities. Volume II, Diseases of importance in Developing Countries / part two of a two-part Study by the Committee on Issues and Priorities for New Vaccine Development, Division of Health Promotion and Disease Prevention, and Division of International Health, Institute of Medicine

Published Washington, D.C. : National Academy Press, 1986

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Description 1 online resource (1 volume) Contents New Vaccine Development Establishing Priorities -- Copyright -- Acknowledgements -- Preface -- Abstract -- Contents -- Summary -- SELECTION OF CANDIDATES -- DETERMINATION OF HEALTH BENEFITS -- Disease Burden Estimates -- Infant Mortality Equivalence Values -- Total Disease Burden Values -- VACCINE CHARACTERISTICS -- Predictions of Vaccine Development -- Definition of Probable Vaccine Target Population -- Treatment of Vaccine Utilization -- Estimation of Time to Licensure, Time to Vaccine Adoption, and Delay of Vaccination Benefits: Discou .. Estimation of Vaccine Preventable IllnessCalculation of Potential Health Benefits for Each Vaccine -- Cost Calculations -- INTERPRETATION OF RESULTS -- FINDINGS, CONCLUSIONS, RECOMMENDATIONS -- REFERENCE -- 2 Priority Setting for Health-Related Investments: A Review of Methods -- METHODS FOR PROJECT RANKING AND SELECTION -- MULTIATTRIBUTE ACCOUNTING -- MULTIATTRIBUTE SCORING -- DECISION ANALYSIS WITH MULTIPLE OBJECTIVES -- COST-EFFECTIVENESS AND COST-UTILITY ANALYSIS -- BENEFIT-COST ANALYSIS -- SELECTION OF AN APPROACH ISSUES IN PROJECT RANKING METHODOLOGIESSources of Estimates -- Sequential or “Lexicographic� Methods -- Interdependence Among Projects -- The “Portfolio� Question -- SUMMARY -- REFERENCES -- 3 Overview of the Analytic Approach -- METHOD -- Calculation Procedures -- INTERPRETATION OF RESULTS -- GUIDELINES -- Step 1 -- Step 2 -- SUMMARY -- REFERENCE -- 4 Comparison of Disease Burdens -- ELEMENTS OF THE SYSTEM FOR COMPARING MORBIDITY AND MORTALITY BURDENS ARISING FROM VARIOUS DISEASES -- Trade-Off Values Expression of Morbidity and Mortality BurdensProcedures Used in Deriving Disease Estimates -- Limitations of the Current Estimates -- VALUE JUDGMENTS IN QUANTIFYING MORBIDITY AND MORTALITY -- IME Perspective Used in This Study -- The Effect of Adopting Other IME Perspectives -- COMPARISON OF COSTS ASSOCIATED WITH DISEASES -- Estimating Aggregate Direct Costs of Diseases in the Developing World -- Estimating Costs for Diseases in Specific Countries or Regions -- Indirect Costs -- FINDINGS -- LIMITATIONS OF THE PROPOSED SYSTEM -- SUMMARY AND CONCLUSIONS RECOMMENDATIONSREFERENCES -- 5 Predictions on Vaccine Development -- THE NEED FOR PREDICTIONS -- SELECTION OF CANDIDATES -- VACCINE CANDIDATES AND TARGET POPULATIONS -- PREDICTIONS ON VACCINE DEVELOPMENT -- Probability of Successful Development -- Cost of Development -- Time to Licensure -- PREDICTIONS ON VACCINE CHARACTERISTICS -- Efficacy -- Adverse Reactions -- Production Technology, Delivery Requirements, and Cost per Dose -- Number of Doses and Route of Administration -- CONCLUSIONS -- REFERENCE Notes Prepared for the National Institute of Allergy and Infectious Diseases Bibliography Includes bibliographical references and indexes Notes Print version record Subject Vaccines -- Research -- Government policy Vaccination -- United States Vaccination -- Developing countries Health planning. Medical policy. Health Planning Communicable Disease Control Vaccines -- supply & distribution Developing Countries Health Policy MEDICAL -- Health Risk Assessment. MEDICAL -- Epidemiology. Medical policy Health planning Vaccination United States Developing countries Form Electronic book Author Institute of Medicine (U.S.). Committee on Issues and Priorities for New Vaccine Development. National Institute of Allergy and Infectious Diseases (U.S.) ISBN 030956820X 9780309568203

Other Titles Diseases of importance in Developing Countries

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