| Description |
1 online resource (viii, 358 pages) : illustrations (some color) |
| Contents |
Intro; Preface; Contents; 1: Physiology of the Gastrointestinal Lymphatics; 1.1 Introduction; 1.2 Characteristics of Lymph Formation in the Gastrointestinal Lymphatic System; 1.2.1 Recirculation of Plasma Protein Through the Lymphatic System; 1.2.2 Higher Permeability of Albumin Through the Venules in Intestinal Microcirculation; 1.2.3 Modified Staring's Law-Dependent Higher Lymph Formation in Intestinal Microcirculation; 1.3 Characteristics of Lymph Transport in the Gastrointestinal Lymphatic System |
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1.3.1 Heart-Like Spontaneous Contraction-Dependent Lymph Transport in Mesenteric Lymphatics1.3.2 Electrical Characteristics of the Heart-Like Contractions in Mesenteric Collecting Lymphatics; 1.3.3 Aminergic Nerve Fibers-Mediated Changes in Physiological Roles of the Heart-Like Spontaneous Contractions: From Lymph Transport to Lymph Formation; 1.3.3.1 Presence of Vasa Vasorum in the Mesenteric Collecting Lymphatic Walls for Keeping the Spontaneous Contractions; 1.3.3.2 Aminergic Nerve Fibers Are Innervated Densely in the Walls of Mesenteric Collecting Lymphatics |
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1.3.3.3 Excitation of Aminergic Nerve Fibers-Mediated Changes in the Pacemaker Sites of Spontaneous Contractions on Lymphatic Smooth Muscle Cells1.4 Physiological Insights of Sentinel Lymph Node (SLN); 1.4.1 The SLN May Be Defined as It Is Constantly Subjected to Higher Lymph Flow from Physiological Point of View; 1.4.2 Higher Lymph Flow-Induced ATP-Mediated Intercellular Adhesion Molecule (ICAM)-1-Dependent Micrometastasis of Carcinoma Cells in SLN; 1.5 Summary; References; 2: Anatomy of Lymphatics; 2.1 Introduction; 2.1.1 Lymphatics of the Esophagus |
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2.1.1.1 Lateral Cervical Nodes (Internal Jugular Chain)2.1.2 Lymphatics of the Stomach; 2.1.3 Lymphatics of the Colon; 2.1.4 Lymphatics of the Rectum; 2.1.5 Lymphatics Surrounding the Abdominal Aorta (Ganglions Abdomino-Aortiques, Rouvière); 2.2 Conclusion; References; 3: Molecular Mechanisms of Lymph Node Metastasis; 3.1 Lymphangiogenesis; 3.1.1 VEGF-C; 3.1.2 VEGF-D; 3.1.3 VEGFR3; 3.1.4 PDGF-B; 3.1.5 Angiopoietin-2; 3.1.6 Neuropilin-2; 3.1.7 MicroRNAs; 3.1.8 Other Factors; 3.2 Cell Migration and Lymph Node Metastasis |
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3.2.1 FOXA1 Promotes Lymph Node Metastasis in Esophageal Squamous Cell Carcinoma3.2.2 Wnt-5a Stimulates Cell Migration in Gastric Cancer Cells; 3.2.3 BAMBI Promotes Migration of HCT116 Colon Cancer Cells; 3.3 Cancer Stem Cells and Metastasis; 3.3.1 Esophageal Cancer Stem Cells; 3.3.2 Gastric Cancer Stem Cells; 3.3.3 Colorectal Cancer Stem Cells; 3.4 Biomarkers for Lymph Node Metastasis; 3.4.1 Esophageal Cancer; 3.4.2 Gastric Cancer; 3.4.3 Colorectal Cancer; 3.5 Anti-lymphangiogenic Therapies for Gastrointestinal Cancer; 3.6 Conclusion; References |
| Summary |
This book provides the most comprehensive and up-to-date knowledge of lymph node micrometastasis (LMM) and sentinel node navigation surgery (SNNS) in gastrointestinal cancers. Lymph node metastasis is a critically important prognostic factor in gastrointestinal tract cancers such as tumors of the esophagus, stomach, and colorectum. An understanding of the basic aspects of lymphatics and lymph nodes, including anatomy, histology, physiology, immunology, and molecular biology, is fundamental for physicians who are involved in cancer treatment. Furthermore, owing to the development of molecular and biological methodology, the precise recognition of LMM and its clinical significance have been clarified recently. At the same time, SNNS has actually been anticipated in treatment of breast tumors, and it is now being introduced in gastrointestinal tract cancer. For the application of SNNS, the detection of lymph node metastasis including LMM is extremely significant, because the presence of LMM determines the direction for surgery and chemo and/or radiation therapy. With these considerations in mind, the expert contributors to this book review basic and clinical approaches for LMM and SNNS including methodology for gastrointestinal cancers. Thus this volume benefits not only surgeons who treat gastrointestinal cancers but also clinical oncologists and medical scientists such as physiologists and pathologists |
| Bibliography |
Includes bibliographical references |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed January 29, 2019) |
| Subject |
Lymphatic metastasis.
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Gastrointestinal system -- Cancer
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Gastrointestinal Neoplasms
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Lymphatic Metastasis
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Gastrointestinal system -- Cancer
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Lymphatic metastasis
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| Form |
Electronic book
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| Author |
Natsugoe, Shoji, editor
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| ISBN |
9789811046995 |
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9811046999 |
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9789811046988 |
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9811046980 |
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9789811047008 |
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9811047006 |
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