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Title The histone code and beyond : new approaches to cancer therapy / S.L. Berger, O. Nakanishi, B. Haendler, editors
Published Berlin ; New York : Springer, 2006

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Description 1 online resource (xiv, 209 pages) : illustrations (chiefly color)
Series Ernst Schering Research Foundation workshop ; 57
Ernst Schering Research Foundation workshop ; 57.
Contents The Role of Histone Modifications in Epigenetic Transitions During Normal and Perturbed Development -- Nucleosome Structure and Function -- The Role of Snf2-Related Proteins in Cancer -- Imitation Switch Complexes -- How Is Epigenetic Information on Chromatin Inherited After DNA Replication? -- Polycomb Silencing Mechanisms and Genomic Programming -- CpG Island Methylation and Histone Modifications: Biology and Clinical Significance -- Histone Post-Translational Modifications Regulate Transcription and Silent Chromatin in Saccharomyces cerevisiae -- Histone Acetylation-Mediated Chromatin Compaction During Mouse Spermatogenesis -- Role of Ubiquitin-Like Proteins in Transcriptional Regulation -- Interplay of the SUMO and MAP Kinase Pathways
Summary Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book
Analysis biochemie
biochemistry
celbiologie
cellular biology
levenswetenschappen
life sciences
oncologie
oncology
Biology (General)
Biologie (algemeen)
Bibliography Includes bibliographical references
Notes Print version record
In Springer e-books
Subject Histones.
Cancer -- Research.
Histone Code
Histones
Biomédecine.
Sciences de la vie.
Cancer -- Research
Histones
Form Electronic book
Author Berger, S. L. (Shelley L.)
Nakanishi, O. (Osamu)
Haendler, B. (Bernard)
LC no. 2005932740
ISBN 9783540376330
354037633X
3540278575
9783540278573
9786610745623
6610745625