| Description |
1 online resource |
| Series |
Receptors ; volume 35 |
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Receptors (Series) ; v. 35
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| Contents |
Intro -- Preface -- Contents -- Chapter 1: Gene Structure, Expression, and 5-HT2B Receptor Signaling -- 1 5-HT2B Receptor Gene Expression and Regulation -- 1.1 5-HT2B Receptor Expression -- 1.2 Genomic Organization and Control of the 5-HT2B Receptor Gene HTR2B -- 2 Structure and Pharmacological Impact -- 2.1 5-HT2B Receptor Structure -- 2.2 Selective Agonists -- 2.3 Selective Antagonists -- 2.4 Allosteric Modulators -- 2.5 Biased Agonists -- 3 5-HT2B Receptor Heteromeric Receptor Associations -- 3.1 Heterodimers of Gq-Coupled Protomers: 5-HT2A, 5-HT2B, and 5-HT2C Receptors |
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3.2 Heterodimers Among Gq-Activating Protomers: AT1-5-HT2B Heterodimers -- 4 5-HT2B Receptor Internalization -- 5 5-HT2B Receptor Interacting Proteins -- 6 5-HT2B Receptor Transduction System(s) -- 6.1 In Transfected Cells -- 6.2 Heart -- 6.3 Liver -- 6.4 Lung -- 6.5 Skin -- 6.6 Bones -- 7 5-HT2B Receptor in Cancer Cells -- 7.1 Carcinoid Tumors -- 7.2 Melanoma -- 7.3 Adrenocortical Carcinoma -- 7.4 Hepatocellular Carcinoma -- 7.5 Pancreatic Ductal Adenocarcinomas -- 7.6 T-cell Leukemia -- 7.7 Tumor Angiogenesis -- 8 Outlook and Prospects -- References -- Part I: Development and Growth |
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Chapter 2: Serotonin Function During Embryonic Development: The 5-HT2B Receptor Contribution -- 1 Introduction -- 2 A Main Mediator of Serotonergic Signaling During Embryogenesis: The 5-HT2B Receptor -- 3 Role of 5-HT2B Receptor in Cardio Vascular Development -- 4 Role of 5-HT2B Receptor in Hematopoietic Lineage -- 5 Role of 5-HT2B Receptor in Osteogenesis -- 6 Role of 5-HT2B Receptor in Neural Crest Cells (NCC) -- 6.1 5-HT2B Receptor in Craniofacial Development -- 6.2 5-HT2B Receptor in Ocular Development -- 6.3 5-HT2B Receptor in NCC Derivatives of the Gut |
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6.4 5-HT2B Receptor in NCC Derivatives of the Skin -- References -- Chapter 3: Stem Cells to Decipher the Physiological Roles of 5-HT2B Receptor Signaling -- 1 Introduction -- 2 The 1C11 Neuronal Stem Cell Line to Dissect the Role of 5-HT2BRs in Bioaminergic Neurons -- 2.1 5-HT2BRs are Involved in the Neuronal Differentiation Program of 1C11 Stem Cells -- 2.2 The Onset of Serotonergic Functions Mainly Depends on Post-Transcriptional Controls -- 2.3 Identification of 5-HT2BR Couplings Along the 1C11 Serotonergic Differentiation |
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2.4 The 5-HT2BR Acts as a 5-HT Biosensor that Adjusts 5-HT Levels by Controlling SERT Functionality -- 2.5 5-HT2BR Signaling is Modulated by the Cellular Prion Protein in Serotonergic 1C11 Cells -- 3 Role of the 5-HT2B Receptor in Mineralized Tissues -- 3.1 The 5-HT2BR Controls TNAP Activity During Osteogenic Differentiation of the C1 Mesodermic Stem Cells -- 3.2 Pulpal Stem Cell Lines to Reveal the Critical Role of Serotonergic (5-HT2B,7R) and Dopaminergic (D1,3R) Autoreceptors in Platelet-Mediated Tooth Repair -- 4 Conclusion -- References |
| Summary |
This contributed volume provides a comprehensive assessment of the roles played by 5-HT2B receptors in humans. These receptors have been shown to play an important role is the cardiac, intestinal, and central nervous systems as well as in bone marrow formation and growth. In this book, expert researchers present their findings on molecular and physiological/pathological aspects of 5-HT2B receptors. The molecular section includes a discussion of the genetics of 5-HT2B receptors and impulse control. The physiological section covers their role in many biological systems including the nervous system, the heart, and the lungs |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed April 6, 2021) |
| Subject |
Serotonin -- Receptors
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Serotonin -- Physiological effect
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Receptor, Serotonin, 5-HT2B
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Receptor, Serotonin, 5-HT2B -- physiology
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Receptor, Serotonin, 5-HT2B -- genetics
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Serotonin -- Physiological effect
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Serotonin -- Receptors
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| Form |
Electronic book
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| Author |
Maroteaux, Luc, editor
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|
Monassier, Laurent, editor
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| ISBN |
9783030559205 |
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3030559203 |
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