| Description |
1 online resource (xv, 210 pages) : illustrations (some color) |
| Contents |
Overview: What is gene expression? -- The impact of chromatin -- The basal transcriptional machinery -- Transcription factors -- Linking signal transduction and gene regulation -- Switching genes on and off at the example of nuclear receptors -- Mapping the genome -- Chromatin modifiers -- Genomic imprinting -- The epigenome -- Chromatin remodeling -- Chromatin architecture -- Regulatory RNA |
| Summary |
This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading from students of all the biomedical sciences in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor biding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation |
| Bibliography |
Includes bibliographical references |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed December 10, 2013) |
| Subject |
Genetic regulation.
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Chromatin.
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Transcription factors.
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Gene Expression Regulation
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Chromatin
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Transcription Factors
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Transcription factors
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Chromatin
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Genetic regulation
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| Form |
Electronic book
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| Author |
Molnár, Ferdinand, author.
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| ISBN |
9789400779051 |
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9400779054 |
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9400779046 |
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9789400779044 |
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