| Description |
1 online resource (645 pages) |
| Contents |
Title Page; Copyright Page; Contents; Contributors; Preface to the Fourth Edition; Chapter 1 How it all began: cancer cytogenetics before sequencing; References; Chapter 2 Cytogenetic methods; Sampling for cytogenetic analysis; Chromosome banding; In situ hybridization; Genomic arrays; Large-scale sequencing; Interpretation of cytogenetic data; References; Chapter 3 Cytogenetic nomenclature; Designation of regions and bands; Karyotypic nomenclature; Nomenclature of tumor cell populations; In situ hybridization nomenclature; References |
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Chapter 4 Nonrandom chromosome abnormalities in cancer: an overviewPrimary and secondary neoplasia-associated chromosome abnormalities; Why and how do chromosome aberrations arise?; When do chromosome aberrations arise?; In which cells do chromosome aberrations arise?; Are acquired chromosome aberrations sufficient for neoplastic proliferation?; Do all tumors have chromosome abnormalities, and are such changes present only in neoplastic cells?; General effects of structural and numerical chromosome abnormalities; Net loss of chromosomal material; Net gain of chromosomal material |
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Relocation of sequences with no gain or loss of genetic materialAt what resolution level are neoplasia-associated mutations best studied?; Pathogenetic versus phenotypic tumor classification; References; Chapter 5 From chromosomes to genes: searching for pathogenetic fusions in cancer; Types of fusion genes; Fusion genes involving regulatory elements of the immunoglobulin and T-cell receptor genes; Promoter swapping; Fusion genes coding for fusion proteins; "Out-of-frame" fusion transcripts; Generation of fusion genes; Methods to identify fusion genes; Methodologies based on cytogenetics |
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"Omics" and gene expression-based methodologiesComparative genomic hybridization-based methodology; Protein-based methodologies; DNA-mediated transformation methodology; Clinic-based methodology; Next-generation sequencing-based methodologies; Conclusion; References; Chapter 6 Acute myeloid leukemia; Most AML harbor clonal chromosomal abnormalities; Impact of age; Impact of previous treatment/genotoxic exposure; Impact of gender; Impact of geographic/ethnic origin; Impact of constitutional genetics; Characteristic chromosomal abnormalities in AML; t(1; 3)(p36; q21) [RPN1-PRDM16]; t(1; 21)(p36 |
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Q22) [RUNX1-PRDM16]t(1; 16)(p31; q24) [NFIA-CBFA2T3]; t(1; 11)(p32; q23) [MLL-EPS15]; t(1; 22)(p13; q13) [RBM15-MKL1]; der(1; 7)(q10; p10); t(1; 11)(q21; q23) [MLL-MLLT11]; t(2; 3)(p11)̃)23; q23)̃)28) [MECOM deregulation]; t(2; 11)(p21; q23) [MLL rearrangement]; t(2; 11)(q31; p15) [NUP98-HOXD11(13)]; t(2; 11)(q37; q23) [MLL-SEPT2]; inv(3)(q21q26)/t(3; 3)(q21; q26) [RPN1-MECOM]; t(3; 5)(q25; q35) [NPM1-MLF1]; t(3; 12)(q26; p13) [ETV6-MECOM]; t(3; 21)(q26; q22) [RUNX1-MECOM]; Trisomy 4; t(4; 12)(q12; p13) [CHIC2-ETV6]; t(4; 11)(q21; q23) [MLL-AFF1]; Monosomy 5/del(5q); t(5; 11)(q31 |
| Summary |
The first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations. New contributors reflecting broader international authorship and even greater expertise Greater emphasis throughout on the clinical importance and application of information about cytogenetic and molecular aberrations Includes a complete coverag |
| Notes |
Q23) [MLL-ARHGAP26] |
| Bibliography |
Includes bibliographical references at the end of each chapters and index |
| Notes |
Print version record |
| Subject |
Cancer -- Genetic aspects.
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Cytogenetics.
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Chromosome Disorders -- genetics
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Cytogenetics
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HEALTH & FITNESS / Diseases / General.
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MEDICAL / Clinical Medicine.
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MEDICAL / Diseases.
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MEDICAL / Evidence-Based Medicine.
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MEDICAL / Internal Medicine.
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Cancer -- Genetic aspects.
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Cytogenetics.
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| Form |
Electronic book
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| Author |
Mitelman, Felix
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| ISBN |
9781118795514 |
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1118795512 |
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9781118795538 |
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1118795539 |
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