| Description |
1 online resource (xix, 145 pages) : illustrations |
| Series |
Advances in experimental medicine and biology ; v. 770 |
|
Advances in experimental medicine and biology ; v. 770.
|
| Contents |
Genomics and evolution of the TRIM gene family / Germana Meroni -- The tripartite motif : structure and function / Lucia Micale [and others] -- TRIM proteins as ring finger E3 ubiquitin ligases / Kazuhiro Ikeda and Satoshi Inoue -- PML nuclear bodies and other TRIM-defined subcellular compartments / Elizabeth C. Batty, Kirsten Jensen, and Paul S. Freemont -- TRIM involvement in transcriptional regulation / Florence Cammas [and others] -- TRIM proteins in cancer / Valeria Cambiaghi [and others] -- TRIM proteins and the innate immune response to viruses / Melvyn W. Yap and Jonathan P. Stoye -- The microtubule-associated C-I subfamily of TRIM proteins and the regulation of polarized cell responses / Timothy C. Cox -- MuRFS : specialized members of the TRIM/RBCC family with roles in the regulation of the trophic state of muscle and its metabolism / Olga Mayans and Siegfried Labeit -- Trim proteins in development / Francesca Petrera and Germana Meroni |
| Summary |
The genomic golden age has delivered the sequence of numerous novel genes while leaving us with many unanswered questions about their function. This is particularly true for gene families as, often, members are annotated based on homology rather than function. The tripartite motif family belonged to this category, although, during the last few years, the field boosted an important wealth of biochemical, cellular and physiological breakthrough data. In the first part of this book, we attempt to offer an overview of stateoftheart basic findings on the tripartite motif (TRIM, also known as RBCC) family members and to deal in the second part with their relevant and growing physiological and pathological roles |
| Analysis |
geneeskunde |
|
medicine |
|
biomedische wetenschappen |
|
biomedicine |
|
Medicine (General) |
|
Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| In |
Springer eBooks |
| Subject |
Carrier proteins.
|
|
Carrier Proteins
|
|
SCIENCE -- Life Sciences -- Biochemistry.
|
|
Carrier proteins
|
| Form |
Electronic book
|
| Author |
Meroni, Germana, 1964-
|
| ISBN |
9781461453987 |
|
1461453984 |
|
