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Book Cover
E-book
Author McCullough, Shaun D

Title Epigenetic Toxicology : Core Principles and Applications
Published San Diego : Elsevier Science & Technology, 2018

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Description 1 online resource (430 pages)
Contents Front Cover; Toxicoepigenetics: Core Principles and Applications; Copyright; Contents; Contributors; Editors' Biography; Introduction to the Role of the Epigenome in Health and Disease; Section 1: Histone Modifications and Chromatin Structure; Chapter 1-1: Role of Histone Acetylation and Acetyltransferases in Gene Regulation; Introduction; History and Overview; Nucleosome Assembly; Chromatin Folding; Gene Expression; DNA Damage Repair; Toxicoepigenetic Relevance; Histone Acetyltransferases; Families and Structures; Regulation of HATs; Transcriptional Activation; HAT Complexes
SAGA Transcription Regulatory ComplexNuA4 Transcription Regulatory Complex; Elongator Complex; Chromatin Remodeling Complexes; Global Histone Acetylation; Role of Histone Acetyltransferases in Gene Activation; Recruitment of Transcriptional Machinery; Active Genes; Inducible/Repressed Genes; Environmental Exposure; Histone Deacetylases; Families; Catalytic Mechanisms and Structures; Regulation of HDAC Activity; Role of HDACs at Active Genes; Deacetylation and Gene Repression; HDAC Complexes; Conclusion and Perspectives; References
Chapter 1-2: The Role of Histone Methylation and Methyltransferases in Gene RegulationIntroduction; Site Specificity of Histone Methylation; Lysine Methylation; H2BK5 Methylation; H3K4 Methylation; H3K9 Methylation; H3K27 Methylation; H3K36 Methylation; H3K79 Methylation; H4K20 Methylation; H4K5 Methylation; Arginine Methylation; Glutamine Methylation; Regulation of Histone Methylation; Posttranscriptional Modifications; Noncoding RNAs; Regulation of Xenobiotic Biotransformation-Related Genes by Histone Methylation; Histone Methylation and Human Diseases; Histone Methylation and Cancer
Histone Methylation and Neurological DisordersHistone Methylation and Other Diseases; Histone Methylation and the Toxicity of Chemicals; Heavy Metals; Endocrine Disruptors (EDCs); Human Genotoxic Chemical Carcinogens From Occupational and Environmental Exposure; Other Xenobiotics; Conclusion; References; Chapter 1-3: Chromatin Accessibility as a Strategy to Detect Changes Associated With Development, Disease, and Exposure a ... ; Chromatin Accessibility as a Marker of Cell Lineage; Methods for Determining Chromatin Architecture and Accessibility; DNase I Hypersensitivity Assays
Micrococcal Nuclease AssaysFormaldehyde Assisted Isolation of Regulatory Elements (FAIRE); Assay for Transposase-Accessible Chromatin (ATAC); Nucleosome Occupancy and Methylome Sequencing (NOMe-seq); Single Cell Assays for Determining Chromatin Accessibility in Heterogenous Cell Populations; Chromatin Accessibility and Disease; Understanding How Environmental Factors Influence Chromatin Accessibility; Chromatin Accessibility and Cancer; Chromatin Signature as a Diagnostic and Therapeutic Target in Cancer; References; Further Reading
Notes Chapter 1-4: Implications for Chromatin Biology in Toxicology
Print version record
Form Electronic book
Author Dolinoy, Dana
ISBN 9780128124345
0128124342