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Book Cover
E-book
Author Matthews, David J. (David John), 1965-

Title Targeting protein kinases for cancer therapy / David J. Matthews, Mary E. Gerritsen
Published Hoboken, N.J. : Wiley, ©2010

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Description 1 online resource (xiii, 702 pages) : illustrations (chiefly color)
Contents Kinases and cancer -- Protein kinase structure, function, and regulation -- Receptor tyrosine kinases -- Nonreceptor tyrosine kinases -- Intracellular signal transduction cascades -- Cell cycle control -- Structural biochemistry of kinase inhibitors -- Tyrosine kinase inhibitors -- Angiokinase inhibitors -- Intracellular signaling kinase inhibitors -- Current challenges and future directions
Summary An expert guide to targeting protein kinases in cancer therapy. Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharma-ceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapydefines the structural features of protein kinases and examines their cellular func-tions. Combining kinase biology with
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Protein kinases -- Inhibitors -- Therapeutic use
Antineoplastic agents.
Protein kinases.
Drug resistance in cancer cells.
Neoplasms -- drug therapy
Protein Kinase Inhibitors -- therapeutic use
Drug Discovery
Drug Resistance, Neoplasm
Protein Kinases -- physiology
Protein-Tyrosine Kinases -- antagonists & inhibitors
Protein Kinases
MEDICAL -- Pharmacology.
Drug resistance in cancer cells
Antineoplastic agents
Protein kinases
Form Electronic book
Author Gerritsen, Mary E
LC no. 2009020804
ISBN 9780470555293
0470555297
9780470555286
0470555289
1118210778
9781118210772
1282551280
9781282551282
9786612551284
6612551283