Limit search to available items
Book Cover
E-book

Title Mucosal T cells / volume editor, Thomas T. MacDonald
Published Basel ; New York : Karger, 1998

Copies

Description 1 online resource (xii, 241 pages) : illustrations (some color)
Series Chemical immunology ; v. 71
Chemical immunology ; v. 71
Contents Phenotypes of T cells in the gut -- T-cell receptor usage in the intestine -- Mucosal T cell-epithelial cell interactions -- [beta]7 integrins and their ligands in lymphocyte migration to the gut -- [gamma delta]T cells: bodyguards and/or sleepers in the gut -- Thymus-independent development of gut T cells -- Lamina propria T cells -- T cells in mouse models of gut inflammation -- T-cell response to orally administered antigens and its role in the treatment of autoimmune diseases -- T cell response to inhaled antigen -- Role of T cells in asthma -- Th1 and Th2 cells and immunity to intestinal helminths -- T cell and cytokine regulation of IgA response
Summary There are more T cells in the gastrointestinal tract and lung than in the rest of the body combined. The aim of this book is to cover all the important aspects of the biology of these cells in animals and in man. Basic observations are described as well as disease states where aberrant activation of mucosal T cells causes tissue damage. The continuing discovery of features of mucosal T cells which make them different from T cells in the periphery is a consistent theme throughout the text. Topics discussed include new developments in understanding why the characteristic response of mucosal T cells to soluble antigens is tolerance, the role of the gut epithelium in intestinal immunity, the molecular basis by which T cells home to the gut mucosa, the functions of gammadelta T cells, the discovery of a new lymphoid organ - the cryptopatch - in the mouse gut, and the remarkable oligoclonality of the alphabeta and gammadelta T cells in the gut epithelium. In more disease-related sections, the way in which T cells play a role in asthma and protection from parasite infection, and how they cause inflammatory bowel disease in man and animals are described. Providing an excellent survey of the field, this book is a valuable resource for both basic scientists and clinicians interested in intestinal immunology and gastrointestinal disease
Bibliography Includes bibliographical references and indexes
Subject T cells -- Physiology
Intestinal mucosa -- Immunology
T-Lymphocytes -- physiology
Autoimmune Diseases -- therapy
Intestinal Mucosa -- immunology
Lung -- immunology
Intestinal mucosa -- Immunology
Form Electronic book
Author MacDonald, Thomas T., 1951-
S. Karger (Firm)
ISBN 9783318003284
331800328X