| Description |
1 online resource (370 pages) |
| Series |
Cambridge medicine |
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Cambridge medicine (Series)
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| Contents |
880-01 Cover; Traumatic Brain and Spinal Cord Injury: Challenges and Developments; Title; Copyright; Dedication; Contents; Contributors; Preface; 1: Current evaluation of TBI epidemiology in an ageing society with improved preventive measures; Introduction; Definitions and classifications; The human cost; The economic cost; Causes, trends and prevention; Trends; Prevention; Traffic-related injury; Trends in traffic-related injury; Prevention of traffic-related injury; Seat belts; Airbags; Helmets; Motorcycle helmets; Bicycle helmets; Child safety seats; Falls; Sport and recreational injury |
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880-01/(S 11: Pediatric brain trauma: what do age-appropriate animal models teach us about the age-at-injury effect-- Introduction -- Cognitive function -- Histological alterations -- Neurodegeneration and cell death -- Traumatic axonal injury -- Cerebral blood flow -- Cerebral metabolism -- Oxidative damage -- Plasticity -- Limitations of TBI models using immature animals -- Conclusion -- References -- 12: The complexity of traumatic axonal injury -- Diffuse axonal injury -- Traumatic axonal injury -- Modeling considerations -- Rotational-acceleration injury -- Open skull impact/impulse injury -- Closed skull impact injury -- Optic nerve stretch injury -- Rapid stretch injury in vitro -- Pathobiology of TAI -- Axolemma permeability -- Ion homeostasis -- Myelin and the role of myelination in axonal vulnerability -- Neurofilaments -- Microtubules and microtubule-based axonal transport -- β-amyloid precursor protein -- Axonal proteases -- Neuronal cell death -- Treatment of traumatic axonal injury -- Conclusions -- Acknowledgements -- References -- 13: Cerebral inflammation after traumatic injury: regulation of secondary damage, repair or both-- Introduction -- Local immune surveillance -- the role of resident microglia -- Astrogliosis and the controversial glial scar -- Neutrophils infiltrate the acutely injured brain -- a primarily detrimental response -- The contribution of infiltrating blood-derived macrophages -- does subtype matter-- Inflammatory cytokines may act as mediators of both neuronal loss and survival -- The pro-inflammatory cytokines IL-1β and TNF -- The multifunctional cytokine IL-6 -- The anti-inflammatory cytokine IL-10 -- Chemokines in TBI -- key mediators of leukocyte recruitment and subsequent inflammation -- The chemokine CCL2 is crucial for macrophage recruitment in the injured CNS |
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Trends in TBI due to sport and recreational injuriesPrevention of TBI in sport and recreational injuries; Assault and self-harm; Trends in assault and self-harm; Prevention in assault and self-harm-gun laws; Occupational injuries; Traumatic brain injury in children; Legislating for prevention; Measuring the effects of preventive strategies; Incidence of traumatic brain injury in the ageing society; Summary; References; 2: Neurotrauma: an emerging epidemic in low- and middle-income countries; Introduction; Traumatic brain injuries; Problems with the epidemiological studies of neurotrauma |
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Burden of TBIsTBIs in low- and middle-income countries; TBI in Nigeria and other African countries; Neurotrauma in Pakistan; Neurotrauma in India; Neurotrauma in Papua New Guinea; Neurotrauma in Vietnam; Neurotrauma in China; Neurotrauma in Taiwan; Pediatric neurotrauma; Prevalence of TBIs; Age and gender; External causes of TBIs; Role of alcohol in TBIs; Risk factors in TBIs; Severity and nature of TBIs; Outcome following TBIs; Economic impact; Prevention and control; Acknowledgement; References; 3: Blast-induced traumatic brain injury and post-traumatic stress disorder; Introduction |
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Historical overview of blast injuriesMechanism of blast injury; Prevalence of traumatic brain injury; Defining traumatic brain injury; Screening for TBI in the military populations; Defining post-traumatic stress disorder; Consequences of traumatic brain injury; Mortality; Epilepsy; Sleep disorders; Substance abuse; Stress; Depression; Biomarkers of blast injury; Neuroimaging of blast injury; Personal protective equipment (PPE) for TBI; Future directions; References; 4: Psychological effects of mild traumatic brain injury: their nature and treatment; Introduction; What is mild TBI? |
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Initial screeningPost-concussional symptoms; Factors associated with continuing post-concussional symptoms; Management of mild traumatic brain injury; Treating physical and neurological symptoms; Pharmacological interventions and homeopathy; Managing cognitive problems; Addressing psychological issues; Sports-related mTBI; Conclusions; References; 5: Developments of neuroimaging techniques to diagnose and visualize white matter damage; Introduction; Pathophysiology of traumatic brain injury; Traumatic axonal injury; The imaging of blood and blood products: susceptibility weighted imaging |
| Summary |
This book covers the medical and pathological issues related to neurotrauma and its often devastating consequences. This volume is divided into two sections, one covering the brain, the other the spinal cord. Each section discusses the following topics: The demographic in the developed and developing world where neurotrauma is witnessing a massive expansion. Major clinical issues including advanced semi-experimental monitoring techniques utilized by neurosurgeons and intensivists and the potential use of identifying markers of tissue injury. Overview of major pathophysiological changes. The development of animal models; successes and limitations. Past, current and future therapeutic strategies including rehabilitative opportunities. Presenting the most up-to-date clinical and experimental research in neurotrauma, this volume is essential reading for neurologists, neurosurgeons, intensive care physicians and rehabilitative physicians |
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Presents the most up-to-date clinical and experimental research in neurotrauma in an illustrated, accessible, comprehensive volume |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Brain -- Wounds and injuries.
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Spinal cord -- Wounds and injuries.
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Brain damage.
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Brain Injuries
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Brain Injuries -- therapy
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Spinal Cord Injuries
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Spinal Cord Injuries -- therapy
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Brain Damage, Chronic
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MEDICAL -- Surgery -- Neurosurgery.
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Brain damage
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Brain -- Wounds and injuries
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Spinal cord -- Wounds and injuries
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| Form |
Electronic book
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| Author |
Morganti-Kossmann, Cristina, 1960-
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Raghupathi, Ramesh
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Maas, Andrew I. R
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| ISBN |
9781139528207 |
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1139528203 |
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9781107007437 |
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1107007437 |
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9781139525817 |
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1139525816 |
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9781139030564 |
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1139030566 |
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9781283521901 |
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1283521903 |
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9781139527019 |
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1139527010 |
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