| Description |
1 online resource (408 pages) |
| Series |
Advances in Experimental Medicine and Biology ; v. 1253 |
|
Advances in experimental medicine and biology ; v. 1253.
|
| Contents |
Intro -- Preface -- Contents -- Editors and Contributors -- Part I Introduction -- 1 Epigenetics in Health and Disease -- 1.1 Introduction -- 1.2 The Science Behind Epigenetics -- 1.3 Epigenetics and Human Disease -- 1.4 The Clinical Application of Epigenetics -- 1.4.1 Epigenetic Biomarkers -- 1.4.2 Epigenetic Therapy -- 1.5 Epigenetic in Diseases -- 1.5.1 The Role of Epigenetics in Cancer -- 1.5.2 The Role of Epigenetics in Immune Diseases -- 1.5.3 Role of Epigenetics in Endocrine Diseases -- 1.5.4 The Role of Epigenetics in Respiratory System Diseases |
|
1.5.5 The Role of Epigenetics in Dermatologic Disorders -- 1.5.6 Role of Epigenetics in Cardiovascular Diseases -- 1.5.7 The Role of Epigenetics in Gastrointestinal Tract Diseases -- 1.6 Discussion -- 1.7 Conclusion -- References -- 2 The Development of Epigenetics in the Study of Disease Pathogenesis -- 2.1 The History and Discovery of the Basic Mechanics of Epigenetics -- 2.1.1 Experimental Observations: Setting the Stage for the Discovery of Epigenetic Mechanisms -- 2.1.2 Getting to the Substance of the Matter: Discoveries of Physical Mechanisms of Epigenetic Control |
|
2.1.3 A New Epigenetic Role for RNA -- 2.2 Epigenetics Moves Mainstream and Meets the Clinic -- 2.2.1 The Epigenetics of Aging -- 2.2.2 The Concept of an Epigenetic Clock -- 2.2.3 Epigenetic Effects of Antiaging Interventions -- 2.3 Epigenetic Modifications as Biomarkers of Disease -- 2.4 Epigenetics in the Modern World: Using Big Data to Understand the Pathogenesis of Complex Diseases in the Present Day -- 2.5 Summary -- References -- 3 Epigenetic Methods and Twin Studies -- 3.1 Introduction -- 3.2 Epigenetic Methods Applied to Rheumatic Diseases |
|
3.3 Epigenetic Twin Studies in Rheumatic Diseases -- 3.4 Conclusions -- References -- Part II Allergic Diseases -- 4 The Role of Genetics, the Environment, and Epigenetics in Atopic Dermatitis -- 4.1 Introduction -- 4.2 Prevalence -- 4.3 Clinical Features -- 4.4 Diagnosis -- 4.5 Pathogenesis -- 4.5.1 Skin Barrier -- 4.5.2 Skin Barrier and AD -- 4.5.3 Immune Imbalance of AD -- 4.5.4 Interaction of Skin Barrier and Immune Function in AD -- 4.5.5 Environmental Factors -- 4.6 GWAS in AD -- 4.7 Epigenetics and AD -- 4.7.1 Epigenetic Studies on the Skin Barrier |
|
4.7.2 Epigenetic Studies on the Immune System -- 4.7.3 miRNAs in AD -- 4.7.4 Epigenetics Studies in AD Patients -- 4.8 Conclusion -- References -- 5 The Epigenetics of Food Allergy -- 5.1 Introduction -- 5.2 Biological Processes in Food Allergy -- 5.3 Genetics -- 5.3.1 Family History -- 5.3.2 Genes Involved in Food Allergy -- 5.4 The Environment -- 5.4.1 The Effect of Early Introduction of Foods -- 5.4.2 The Microbiome -- 5.5 Epigenetic Research in Food Allergies -- 5.6 Conclusions -- References -- 6 Epigenetics and the Environment in Airway Disease: Asthma and Allergic Rhinitis |
| Summary |
This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts - the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases |
| Notes |
6.1 Introduction |
|
Print version record |
| Subject |
Epigenetics.
|
|
Immunogenetics.
|
|
Immunogenetics
|
|
Epigenetics
|
|
Immunogenetics
|
| Form |
Electronic book
|
| Author |
Chang, Christopher C.
|
|
Lu, Qianjin (Professor of dermatology)
|
| ISBN |
9789811534492 |
|
9811534497 |
|
